Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 5/20 | 0.60 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.57 |
| ▸ | DPP4 | P27487 | 2/20 | 0.53 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.53 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.53 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.53 |
| ▸ | FAP | Q12884 | 1/20 | 0.53 |
| ▸ | F10 | P00742 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7340878 | 1.00 | F2 (0.60) | F2PRSS1DPP4DPP8DPP9 | |
| SCHEMBL7047472 | 0.91 | F2 (0.56) | F2PRSS1DPP4DPP8DPP9 | |
| SCHEMBL7050978 | 0.91 | F2 (0.56) | F2PRSS1DPP4DPP8DPP9 | |
| SCHEMBL7113614 | 0.91 | F2 (0.56) | F2PRSS1DPP4DPP8DPP9 | |
| SCHEMBL14020742 | 0.87 | F2 (0.66) | F2PRSS1DPP4DPP8DPP9 | |
| SCHEMBL7460574 | 0.86 | F2 (0.79) | F2PRSS1DPP4DPP8DPP9 | |
| SCHEMBL7460570 | 0.86 | F2 (0.79) | F2PRSS1DPP4DPP8DPP9 | |
| SCHEMBL14020729 | 0.86 | F2 (0.67) | F2PRSS1DPP4DPP8DPP9 | |
| SCHEMBL7338542 | 0.85 | F2 (0.54) | F2PRSS1F10 | |
| SCHEMBL7346744 | 0.85 | F2 (0.54) | F2PRSS1F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583146-A | Heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-10 | — | — | US | disclosed |
| EP-0601459-A2 | Sulfonamido heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-06-15 | — | — | EP | disclosed |