Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.66 |
| ▸ | TYMS | P04818 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7342631 | 0.88 | TYMS (0.56) | HTR2CTYMSKDM4EMEN1ALDH1A1 | |
| SCHEMBL7347836 | 0.86 | NPSR1 (0.54) | HTR2CTYMSMAPTHPGDKMT2A | |
| SCHEMBL10845552 | 0.82 | CUL4A (0.50) | — | |
| SCHEMBL10845391 | 0.82 | PDE2A (0.47) | HTR2C | |
| SCHEMBL10844640 | 0.82 | HTR2C (0.66) | HTR2CTP53 | |
| SCHEMBL10847214 | 0.80 | TP53 (0.47) | HTR2CTP53 | |
| SCHEMBL10845502 | 0.80 | TP53 (0.47) | TP53 | |
| SCHEMBL7340914 | 0.80 | TYMS (0.68) | TYMSTP53KDM4EMEN1ALDH1A1 | |
| SCHEMBL10845557 | 0.79 | HTR2C (0.63) | HTR2CTP53MAPT | |
| SCHEMBL10844118 | 0.79 | HTR2C (1.00) | HTR2CTP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4780464-A | CARDIOVASCULAR DISORDERS | WARNER-LAMBERT COMPANY (US) | 1988-10-25 | — | — | US | disclosed |
| US-4623725-A | [1,2,4]Triazolo[4,3-a]quinoxaline-4-amine derivatives | PFIZER INC. (US) | 1986-11-18 | — | — | US | disclosed |
| EP-0107455-B1 | TRIAZOLOQUINOXALINES AS ANTIDEPRESSANTS AND ANTIFATIGUE AGENTS | PFIZER INC. (US) | 1986-07-09 | — | — | EP | disclosed |
| US-4547501-A | Method of using [1,2,4]triazolo[4,3-a]quinoxaline-4-amine derivatives as antidepressant and antifatigue agents | PFIZER INC. (US) | 1985-10-15 | — | — | US | disclosed |
| US-4495187-A | Method of using [1,2,4]triazolo[4,3-a]quinoxaline-4-amine derivatives as antidepressant and antifatigue agents | PFIZER INC. (US) | 1985-01-22 | — | — | US | disclosed |
| EP-0107455-A1 | Triazoloquinoxalines as antidepressants and antifatigue agents | PFIZER INC. (US) | 1984-05-02 | — | — | EP | disclosed |