Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Dl-Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | BLM | P54132 | 2/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | MPO | P05164 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | MC4R | P32245 | 2/20 | 0.52 |
| ▸ | MC5R | P33032 | 1/20 | 0.52 |
| ▸ | MC3R | P41968 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tryptophan SCHEMBL7341872 | 1.00 | KMT2A (0.57) | KMT2AKDM4ELMNAMAPTTSHR | |
| Dl-Tryptophan SCHEMBL27622241 | 0.94 | KMT2A (0.64) | KMT2AKDM4ELMNAMAPTTSHR | |
| Dl-Tryptophan SCHEMBL27650699 | 0.94 | KMT2A (0.65) | KMT2AKDM4ELMNAMAPTTSHR | |
| Dl-Tryptophan SCHEMBL29176794 | 0.94 | KMT2A (0.65) | KMT2AKDM4ELMNAMAPTTSHR | |
| Dl-Tryptophan SCHEMBL26977489 | 0.93 | KMT2A (0.67) | KMT2AKDM4ELMNAMAPTTSHR | |
| Dl-Tryptophan SCHEMBL27641172 | 0.92 | IL23R (0.50) | KMT2AKDM4ELMNAMAPTTSHR | |
| Dl-Tryptophan SCHEMBL29163825 | 0.92 | KMT2A (0.60) | KMT2AKDM4ELMNAMAPTTSHR | |
| Dl-Tryptophan SCHEMBL21219049 | 0.90 | KMT2A (0.71) | KMT2AKDM4ELMNAMAPTTSHR | |
| Tryptophan SCHEMBL4654771 | 0.89 | KMT2A (0.73) | KMT2AKDM4ELMNAMAPTTSHR | |
| Dl-Tryptophan SCHEMBL28340345 | 0.87 | KMT2A (0.56) | KMT2AKDM4ELMNAMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003084465-A2 | MODELING BIOLOGICAL SYSTEMS | SRI INTERNATIONAL, INC. (US) | 2003-10-16 | — | — | WO | disclosed |