Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MYC | P01106 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | AGER | Q15109 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4290255 | 0.83 | NAPRT (0.58) | NAPRTSMN1; SMN2LMNAKDM4ETDP1 | |
| SCHEMBL24963302 | 0.83 | NAPRT (0.44) | NAPRTSMN1; SMN2LMNAP2RX7KDM4E | |
| SCHEMBL29448035 | 0.83 | NAPRT (0.58) | NAPRTSMN1; SMN2LMNAKDM4ETDP1 | |
| SCHEMBL16977992 | 0.82 | KMT2A (0.43) | NAPRTSMN1; SMN2LMNAP2RX7KDM4E | |
| SCHEMBL3463758 | 0.81 | NAPRT (0.56) | NAPRTSMN1; SMN2LMNAKDM4ETDP1 | |
| SCHEMBL2770958 | 0.81 | PARP1 (0.51) | NAPRTSMN1; SMN2LMNAP2RX7KDM4E | |
| Lithium Ion SCHEMBL3463755 | 0.80 | NAPRT (0.42) | NAPRTSMN1; SMN2LMNAP2RX7KDM4E | |
| SCHEMBL26054706 | 0.79 | NAPRT (0.41) | NAPRTSMN1; SMN2LMNAP2RX7KDM4E | |
| SCHEMBL28344341 | 0.77 | NAPRT (0.40) | NAPRTSMN1; SMN2LMNAP2RX7KDM4E | |
| SCHEMBL29448053 | 0.75 | POLB (0.42) | NAPRTSMN1; SMN2LMNAKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5849735-A | Tricyclic benzazepine vasopressin antagonists | AMERICAN CYANAMID COMPANY (US) | 1998-12-15 | — | — | US | disclosed |
| EP-0804420-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | American Cyanamid Company (US) | 1997-11-05 | — | — | EP | disclosed |
| WO-1996022282-A1 | TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS | AMERICAN CYANAMID COMPANY (US) | 1996-07-25 | — | — | WO | disclosed |