Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 9/20 | 0.67 |
| ▸ | PLG | P00747 | 12/20 | 0.64 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.64 |
| ▸ | KLKB1 | P03952 | 5/20 | 0.64 |
| ▸ | PLAT | P00750 | 5/20 | 0.64 |
| ▸ | F2 | P00734 | 5/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.49 |
| ▸ | KLK1 | P06870 | 8/20 | 0.46 |
| ▸ | KLK6 | Q92876 | 6/20 | 0.46 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7343081 | 1.00 | PLAU (0.67) | PLAUPLGPRSS1KLKB1PLAT | |
| SCHEMBL27570130 | 0.93 | PLAU (0.56) | PLAUPLGPRSS1KLKB1PLAT | |
| Trifluoroacetic Acid SCHEMBL7344126 | 0.92 | PLAU (0.58) | PLAUPLGPRSS1KLKB1PLAT | |
| Trifluoroacetic Acid SCHEMBL7344120 | 0.92 | PLAU (0.58) | PLAUPLGPRSS1KLKB1PLAT | |
| SCHEMBL7345240 | 0.90 | PLAU (0.64) | PLAUPLGPRSS1KLKB1PLAT | |
| SCHEMBL7345579 | 0.89 | PLAU (0.65) | PLAUPLGPRSS1KLKB1PLAT | |
| SCHEMBL7340329 | 0.86 | PLAU (0.63) | PLAUPLGPRSS1KLKB1PLAT | |
| Trifluoroacetic Acid SCHEMBL7335899 | 0.86 | PLAU (0.49) | PLAUPLGPRSS1KLKB1PLAT | |
| SCHEMBL7336457 | 0.85 | NPC1 (0.53) | PLAUPLGPRSS1KLKB1PLAT | |
| SCHEMBL6439043 | 0.82 | PLAU (0.49) | PLAUPLGPRSS1KLKB1PLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6284796-B1 | NAPHTHAMIDINE COMPOUNDS | ABBOTT LABORATORIES | 2001-09-04 | — | — | US | claimed |