SCHEMBL7344948

SCHEMBL7344948

CC(C)(C)NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)OC(C)(C)C

nearest known ligand 0.56

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
PPARG P37231 1/20 0.56
PPARA Q07869 1/20 0.56
CTSS P25774 7/20 0.52
CTSK P43235 6/20 0.52
CTSB P07858 2/20 0.51
CTSL P07711 1/20 0.51
BCL2 P10415 4/20 0.47
MCL1 Q07820 1/20 0.47
ITGB3 P05106 1/20 0.47
ITGA2B P08514 1/20 0.47
ITGA4 P13612 1/20 0.46
ITGB7 P26010 1/20 0.46
HDAC8 Q9BY41 1/20 0.45
AKT1 P31749 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7344956 1.00 PPARG (0.56) PPARGPPARACTSSCTSKCTSB
SCHEMBL6808320 0.89 PPARG (0.57) PPARGPPARACTSSCTSKCTSB
SCHEMBL6808317 0.89 PPARG (0.57) PPARGPPARACTSSCTSKCTSB
SCHEMBL441283 0.87 PPARA (0.68) PPARGPPARACTSSCTSKCTSB
SCHEMBL3784750 0.87 PPARG (0.59) PPARGPPARACTSSCTSKCTSB
SCHEMBL199415 0.87 PPARA (0.68) PPARGPPARACTSSCTSKCTSB
SCHEMBL30912525 0.87 PPARG (0.59) PPARGPPARACTSSCTSKCTSB
SCHEMBL440723 0.87 PPARA (0.68) PPARGPPARACTSSCTSKCTSB
SCHEMBL6674404 0.87 PPARG (0.59) PPARGPPARACTSSCTSKCTSB
SCHEMBL14552051 0.86 PPARG (0.54) PPARGPPARACTSSCTSKCTSB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6423689-B1 Peptidyl calcium channel blockers WARNER-LAMBERT COMPANY 2002-07-23 US disclosed
US-6117841-A USED TO TREAT STROKE, CEREBRAL ISCHEMIA, PAIN, HEAD TRAUMA OR EPILEPSY WARNER-LAMBERT COMPANY (US) 2000-09-12 US disclosed
WO-1998054123-A1 SUBSTITUTED PEPTIDYLAMINE CALCIUM CHANNEL BLOCKERS WARNER-LAMBERT COMPANY (US) 1998-12-03 WO disclosed