Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26364967 | 1.00 | MAPT (0.48) | MAPTKMT2AMEN1CASP3TRPV1 | |
| SCHEMBL7345443 | 1.00 | MAPT (0.48) | MAPTKMT2AMEN1CASP3TRPV1 | |
| SCHEMBL5520042 | 0.95 | MAPT (0.44) | MAPTKMT2AMEN1CASP3TRPV1 | |
| SCHEMBL5520040 | 0.95 | MAPT (0.44) | MAPTKMT2AMEN1CASP3TRPV1 | |
| SCHEMBL14615017 | 0.95 | MAPT (0.44) | MAPTKMT2AMEN1CASP3TRPV1 | |
| SCHEMBL10516777 | 0.89 | PTPN1 (0.41) | MAPTKMT2AMEN1CASP3TRPV1 | |
| SCHEMBL12883157 | 0.86 | MAPT (0.45) | MAPTKMT2AMEN1CYP1A2LMNA | |
| SCHEMBL14499482 | 0.86 | MAPT (0.45) | MAPTKMT2AMEN1CYP1A2LMNA | |
| SCHEMBL26845457 | 0.86 | MAPT (0.45) | MAPTKMT2AMEN1CYP1A2LMNA | |
| SCHEMBL10514962 | 0.85 | KMT2A (0.40) | MAPTKMT2AMEN1CASP3TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115427028-A | Selective Androgen Receptor Covalent Antagonists (SARCA) and methods of use thereof | 田纳西大学研究基金会 | 2022-12-02 | — | — | CN | disclosed |
| EP-0329691-B1 | CARDIOTONIC IMIDAZOLYLPHENYLPYRROL-2-ONES | SCHERING AKTIENGESELLSCHAFT (DE) | 1991-11-21 | — | — | EP | disclosed |
| US-4737511-A | Cardiotonic imidazolylphenylpyrrol-2-ones | SCHERING A.G. (DE) | 1988-04-12 | — | — | US | disclosed |