Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR2 | P21452 | 12/20 | 0.56 |
| ▸ | CACNA1B | Q00975 | 6/20 | 0.54 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.52 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.52 |
| ▸ | CTSS | P25774 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7341412 | 0.96 | TACR2 (0.58) | TACR2CACNA1BITGB3ITGA2BCTSS | |
| SCHEMBL7337619 | 0.91 | CACNA1B (0.57) | TACR2CACNA1BCTSS | |
| SCHEMBL7340969 | 0.91 | CACNA1B (0.57) | TACR2CACNA1BCTSS | |
| SCHEMBL7340635 | 0.91 | CACNA1B (0.56) | TACR2CACNA1BCTSS | |
| SCHEMBL7341622 | 0.89 | PLG (0.58) | TACR2CACNA1BCTSS | |
| SCHEMBL7343417 | 0.89 | CACNA1B (0.58) | CACNA1BCTSS | |
| SCHEMBL7341276 | 0.89 | CACNA1B (0.58) | CACNA1BCTSS | |
| SCHEMBL7345251 | 0.88 | TACR2 (0.60) | TACR2CACNA1BCTSS | |
| SCHEMBL7337268 | 0.87 | TACR2 (0.61) | TACR2ITGB3ITGA2B | |
| SCHEMBL7345374 | 0.87 | CACNA1B (0.66) | CACNA1BITGB3ITGA2BCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0546389-B1 | Piperidylmethyl substituted chroman derivatives as agents for the treatment of diseases of the central nervous system | BAYER AG (DE) | 1996-04-17 | — | — | EP | disclosed |
| EP-0546388-B1 | Azaheterocyclylmethyl-chromans as agents for the treatment of diseases of the central nervous system | BAYER AG (DE) | 1996-03-27 | — | — | EP | disclosed |
| EP-0546389-A1 | Piperidylmethyl substituted chroman derivatives as agents for the treatment of diseases of the central nervous system | BAYER AG (DE) | 1993-06-16 | — | — | EP | disclosed |
| EP-0546388-A1 | Azaheterocyclylmethyl-chromans as agents for the treatment of diseases of the central nervous system | BAYER AG (DE) | 1993-06-16 | — | — | EP | disclosed |