Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | XIAP | P98170 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 4/20 | 0.35 |
| ▸ | AADAT | Q8N5Z0 | 3/20 | 0.34 |
| ▸ | GOT1 | P17174 | 1/20 | 0.34 |
| ▸ | KYAT1 | Q16773 | 1/20 | 0.34 |
| ▸ | KYAT3 | Q6YP21 | 1/20 | 0.34 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7346194 | 1.00 | ANPEP (0.41) | ANPEPHTR2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7346183 | 1.00 | ANPEP (0.41) | ANPEPHTR2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7337703 | 0.82 | MAPK1 (0.39) | ANPEPHTR2AABHD6 | |
| SCHEMBL4989954 | 0.77 | ANPEP (0.50) | ANPEPHTR2ASLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL22612124 | 0.75 | ANPEP (0.51) | ANPEPHTR2ASLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL30630763 | 0.75 | ANPEP (0.51) | ANPEPHTR2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7335861 | 0.71 | NOTUM (0.42) | HTR2ASLC6A4HRH1HTR2BNOTUM | |
| SCHEMBL4992267 | 0.69 | PARP1 (0.48) | ANPEPSMN1; SMN2KCNH2TSHRDPP4 | |
| SCHEMBL13916618 | 0.69 | USP2 (0.40) | ANPEPHTR2AXIAPACELMNA | |
| SCHEMBL4122057 | 0.68 | XIAP (0.54) | ANPEPHTR2AXIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6432944-B1 | ARYLACETAMIDOALANYL DERIVATIVES OF BENZODIAZEPINONES ARE USEFUL FOR INHIBITION OF EXTRACELLULAR DEPOSITION OF BETA-AMYLOID PEPTIDE, THUS TREATS AMYLOIDOSIS, ALZHEIMER'S DISEASE AND DOWN'S SYNDROME | BRISTOL-MYERS SQUIBB COMPANY | 2002-08-13 | — | — | US | disclosed |
| US-20020022621-A1 | Benzodiazepinone beta -amyloid inhibitors: arylacetamidoalanyl derivatives | BRISTOL-MYERS SQUIBB COMPANY | 2002-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020022621-A1 | Benzodiazepinone beta -amyloid inhibitors: arylacetamidoalanyl derivatives | APP, BACE1, PSEN1 | ANPEP 250/4885HTR2A 289/4885SLC6A2 758/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.