SCHEMBL7346208

SCHEMBL7346208

O=C1NCC1N1C(=O)c2ccccc2C1=O

nearest known ligand 0.67

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 15/20 0.57
DDB1 Q16531 13/20 0.57
IKZF3 Q9UKT9 2/20 0.57
ALDH1A1 P00352 1/20 0.57
CHRM2 P08172 1/20 0.57
OPRM1 P35372 1/20 0.57
CYP1A2 P05177 1/20 0.57
TSHR P16473 1/20 0.57
TDP1 Q9NUW8 1/20 0.57
TNF P01375 1/20 0.43
IL1B P01584 1/20 0.43
TBXA2R P21731 1/20 0.43
IKZF1 Q13422 1/20 0.43
HTR2A P28223 1/20 0.39
HTR2C P28335 1/20 0.39
HTR2B P41595 1/20 0.39
CASP3 P42574 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22502405 1.00 CRBN (0.57) CRBNDDB1IKZF3ALDH1A1CHRM2
SCHEMBL17169704 0.86 CRBN (0.59) CRBNDDB1IKZF3ALDH1A1CHRM2
SCHEMBL2065573 0.83 CRBN (0.65) CRBNDDB1IKZF3ALDH1A1CHRM2
SCHEMBL31013928 0.83 CRBN (0.65) CRBNDDB1IKZF3ALDH1A1CHRM2
SCHEMBL31013981 0.83 CRBN (0.65) CRBNDDB1IKZF3ALDH1A1CHRM2
SCHEMBL845434 0.80 CRBN (0.57) CRBNDDB1IKZF3ALDH1A1CHRM2
SCHEMBL3125601 0.79 CRBN (0.55) CRBNDDB1IKZF3ALDH1A1CHRM2
SCHEMBL18263933 0.79 CRBN (0.55) CRBNDDB1IKZF3ALDH1A1CHRM2
SCHEMBL20046006 0.78 CRBN (0.46) CRBNDDB1IKZF3ALDH1A1CHRM2
SCHEMBL20045999 0.78 CRBN (0.46) CRBNDDB1IKZF3ALDH1A1CHRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020206381-A1 CEPHEM COMPOUNDS WITH LATENT REACTIVE GROUPS AND METHODS OF USING AND MAKING SAME SUTTON LARRY D (US) 2020-10-08 WO disclosed
EP-0776330-B1 PHOTOLABILE COMPOUNDS AND METHODS FOR THEIR USE AFFYMAX TECH NV (AN) 2003-08-20 EP disclosed
EP-0776330-A4 PHOTOLABILE COMPOUNDS AND METHODS FOR THEIR USE AFFYMAX TECH NV (AN) 1999-07-28 EP disclosed
US-5917016-A USEFUL AS PHOTOCLEAVABLE LINKING GROUPS IN SOLID PHASE SYNTHESIS AFFYMAX TECHNOLOGIES N.V. (GB) 1999-06-29 US disclosed
US-5739386-A PHOTOCLEAVABLE LINKING GROUPS IN SOLID PHASE SYNTHESIS AFFYMAX TECHNOLOGIES N.V. (GB) 1998-04-14 US disclosed
WO-1997042170-A1 A PROCESS FOR THE PREPARATION OF AZETIDINONES BIOCHIMICA OPOS S.P.A. (IT) 1997-11-13 WO disclosed
EP-0776330-A2 PHOTOLABILE COMPOUNDS AND METHODS FOR THEIR USE AFFYMAX TECHNOLOGIES N.V. (AN) 1997-06-04 EP disclosed
WO-1996016333-A1 METHODS FOR SYNTHESIZING DIVERSE COLLECTIONS OF β-LACTAM COMPOUNDS AFFYMAX TECHNOLOGIES, N.V. (AN) 1996-05-30 WO disclosed
WO-1996000378-A1 PHOTOLABILE COMPOUNDS AND METHODS FOR THEIR USE AFFYMAX TECHNOLOGIES N.V. (AN) 1996-01-04 WO disclosed
US-5395931-A 6-amido-1-methyl-2-(substituted-thio)carbapenems MERCK & CO., INC. (US) 1995-03-07 US disclosed
US-5183887-A Antibiotics, bactericides MERCK & CO., INC. (US) 1993-02-02 US disclosed
US-5055463-A Bactericides MERCK & CO., INC. (US) 1991-10-08 US disclosed
EP-0381534-A1 Novel spirocyclic 6-amido-carbapenems MERCK & CO. INC. (US) 1990-08-08 EP disclosed
EP-0350210-A2 Novel 6-amido-1-methyl-2-(substituted-thio)-carbapenems MERCK & CO. INC. (US) 1990-01-10 EP disclosed
EP-0138113-B1 PROCESS FOR THE PREPARATION OF OPTICALLY UNIFORM AZETIDINONES F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1988-04-27 EP disclosed
EP-0138113-A1 Process for the preparation of optically uniform azetidinones F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1985-04-24 EP disclosed
EP-0052299-A1 2-Oxoazetidine derivatives and production thereof Takeda Chemical Industries, Ltd. (JP) 1982-05-26 EP disclosed