Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.56 |
| ▸ | MGAM | O43451 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | SI | P14410 | 1/20 | 0.50 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | ADH5 | P11766 | 3/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.43 |
| ▸ | PDE4A | P27815 | 5/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10755622 | 0.88 | PDE3B (0.62) | PDE3BPDE3AMGAMGAASI | |
| Hydrochloric Acid SCHEMBL10759777 | 0.87 | PDE3B (0.60) | PDE3BPDE3AMGAMGAASI | |
| SCHEMBL7340182 | 0.85 | PDE3B (0.52) | PDE3BPDE3AMGAMGAASI | |
| SCHEMBL7340318 | 0.80 | PDE3B (0.40) | PDE3BPDE3AMGAMGAASI | |
| SCHEMBL10759148 | 0.80 | PDE3B (0.49) | PDE3BPDE3AMGAMGAASI | |
| Hydrochloric Acid SCHEMBL10761022 | 0.79 | PDE3B (0.48) | PDE3BPDE3AMGAMGAASI | |
| SCHEMBL10757838 | 0.77 | PDE3B (0.52) | PDE3BPDE3AMGAMGAASI | |
| SCHEMBL7341161 | 0.77 | PDE3B (0.54) | PDE3BPDE3AMGAMGAASI | |
| SCHEMBL10759143 | 0.76 | PDE3B (0.57) | PDE3BPDE3AMGAMGAASI | |
| SCHEMBL7341034 | 0.76 | PDE3B (0.62) | PDE3BPDE3AADH5PDE4BPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0329691-B1 | CARDIOTONIC IMIDAZOLYLPHENYLPYRROL-2-ONES | SCHERING AKTIENGESELLSCHAFT (DE) | 1991-11-21 | — | — | EP | claimed |
| EP-0329691-A1 | CARDIOTONIC IMIDAZOLYLPHENYLPYRROL-2-ONES. | SCHERING AG (DE) | 1989-08-30 | — | — | EP | claimed |
| WO-1988003531-A1 | CARDIOTONIC IMIDAZOLYLPHENYLPYRROL-2-ONES | SCHERING AKTIENGESELLSCHAFT (DE) | 1988-05-19 | — | — | WO | claimed |
| US-4737511-A | Cardiotonic imidazolylphenylpyrrol-2-ones | SCHERING A.G. (DE) | 1988-04-12 | — | — | US | claimed |
| EP-0329691-B1 | CARDIOTONIC IMIDAZOLYLPHENYLPYRROL-2-ONES | SCHERING AKTIENGESELLSCHAFT (DE) | 1991-11-21 | — | — | EP | disclosed |
| EP-0329691-A1 | CARDIOTONIC IMIDAZOLYLPHENYLPYRROL-2-ONES. | SCHERING AG (DE) | 1989-08-30 | — | — | EP | disclosed |
| WO-1988003531-A1 | CARDIOTONIC IMIDAZOLYLPHENYLPYRROL-2-ONES | SCHERING AKTIENGESELLSCHAFT (DE) | 1988-05-19 | — | — | WO | disclosed |
| US-4737511-A | Cardiotonic imidazolylphenylpyrrol-2-ones | SCHERING A.G. (DE) | 1988-04-12 | — | — | US | disclosed |