Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 10/20 | 0.62 |
| ▸ | AVPR1A | P37288 | 10/20 | 0.62 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.59 |
| ▸ | HTR1A | P08908 | 1/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.59 |
| ▸ | OXTR | P30559 | 1/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.59 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7352821 | 0.90 | AVPR2 (0.65) | AVPR2AVPR1AABCB11HTR1ACHRM1 | |
| SCHEMBL7344949 | 0.90 | AVPR2 (0.65) | AVPR2AVPR1AABCB11HTR1ACHRM1 | |
| SCHEMBL7345411 | 0.89 | AVPR2 (0.64) | AVPR2AVPR1AABCB11HTR1ACHRM1 | |
| SCHEMBL7353750 | 0.89 | AVPR2 (0.64) | AVPR2AVPR1AABCB11HTR1ACHRM1 | |
| SCHEMBL7345379 | 0.89 | AVPR2 (0.63) | AVPR2AVPR1AABCB11HTR1ACHRM1 | |
| SCHEMBL7345137 | 0.86 | AVPR2 (0.71) | AVPR2AVPR1AABCB11HTR1ACHRM1 | |
| SCHEMBL7346279 | 0.86 | AVPR2 (0.70) | AVPR2AVPR1AABCB11HTR1ACHRM1 | |
| SCHEMBL7348652 | 0.86 | AVPR2 (0.70) | AVPR2AVPR1AABCB11HTR1ACHRM1 | |
| SCHEMBL7344248 | 0.84 | AVPR2 (0.68) | AVPR2AVPR1AABCB11HTR1ACHRM1 | |
| SCHEMBL7344056 | 0.84 | AVPR2 (0.65) | AVPR2AVPR1AABCB11HTR1ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5985869-A | USEFUL AS VASODILATORS, HYPOTENSIVE AGENTS, WATER DIURETICS, PLATELET AGGLUTINATION INHIBITORS | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1999-11-16 | — | — | US | disclosed |
| US-5753677-A | Benzoheterocyclic compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| US-5559230-A | VASOPRESSIN ANTAGONISTS, QUINOLINES, BENZAZEPINES, VASODILATION, HYPOTENSIVE AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-09-24 | — | — | US | disclosed |
| EP-0450097-B1 | BENZOHETEROCYCLIC COMPOUNDS | OTSUKA PHARMA CO LTD (JP) | 1996-04-24 | — | — | EP | disclosed |
| WO-1994001113-A1 | OXYTOCIN ANTAGONIST | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1994-01-20 | — | — | WO | disclosed |
| WO-1991005549-A1 | BENZOHETEROCYCLIC COMPOUNDS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-05-02 | — | — | WO | disclosed |