Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 19/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | GLA | P06280 | 1/20 | 0.59 |
| ▸ | CASP1 | P29466 | 1/20 | 0.59 |
| ▸ | CASP7 | P55210 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7299762 | 0.89 | PDE5A (1.00) | PDE5A | |
| SCHEMBL7299809 | 0.89 | PDE5A (1.00) | PDE5A | |
| SCHEMBL7308957 | 0.88 | PDE5A (1.00) | PDE5A | |
| SCHEMBL6197740 | 0.87 | PDE5A (0.77) | PDE5AKDM4EALDH1A1GLACASP1 | |
| SCHEMBL6198127 | 0.87 | PDE5A (0.77) | PDE5AKDM4EALDH1A1GLACASP1 | |
| SCHEMBL6199730 | 0.86 | PDE5A (0.78) | PDE5A | |
| SCHEMBL7302334 | 0.86 | PDE5A (0.88) | PDE5A | |
| SCHEMBL3842772 | 0.86 | PDE5A (0.75) | PDE5A | |
| SCHEMBL6197745 | 0.84 | PDE5A (0.73) | PDE5AKDM4EALDH1A1GLACASP1 | |
| SCHEMBL7296916 | 0.84 | PDE5A (0.83) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6200980-B1 | ADMINISTERING PHENYL PURINONE COMPOUND FOR TREATING PRECANCEROUS LEISONS | CELL PATHWAYS, INC. | 2001-03-13 | — | — | US | disclosed |
| WO-1993007149-A1 | PYRAZOLOPYRIMIDINONE ANTIANGINAL AGENTS | PFIZER LIMITED (GB) | 1993-04-15 | — | — | WO | disclosed |