Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1S | Q13698 | 10/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.74 |
| ▸ | TSHR | P16473 | 2/20 | 0.74 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.74 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.74 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.74 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.74 |
| ▸ | HRH2 | P25021 | 1/20 | 0.74 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.74 |
| ▸ | SCN1A | P35498 | 1/20 | 0.74 |
| ▸ | SCN4A | P35499 | 1/20 | 0.74 |
| ▸ | HTT | P42858 | 1/20 | 0.74 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.74 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.74 |
| ▸ | PLAUR | Q03405 | 1/20 | 0.74 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.74 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.74 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9385669 | 1.00 | CACNA1S (0.79) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| SCHEMBL29376769 | 1.00 | CACNA1S (0.79) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| SCHEMBL7348984 | 1.00 | CACNA1S (0.79) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| SCHEMBL7273620 | 1.00 | CACNA1S (0.79) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| SCHEMBL7264295 | 1.00 | CACNA1S (0.79) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| Hydrochloric Acid SCHEMBL31567938 | 0.99 | CACNA1S (0.78) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| Hydrochloric Acid SCHEMBL9722623 | 0.99 | CACNA1S (0.78) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| Hydrochloric Acid SCHEMBL31567939 | 0.99 | CACNA1S (0.78) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| Hydrochloric Acid SCHEMBL31567940 | 0.99 | CACNA1S (0.78) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| Hydrochloric Acid SCHEMBL9722620 | 0.99 | CACNA1S (0.78) | CACNA1SCYP3A4TSHRABCB11LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0702009-B1 | Method for the preparation of pharmaceutically active benzothiazepine derivatives | ORION CORP FERMION (FI) | 1998-07-01 | — | — | EP | claimed |
| US-5663332-A | Method for the preparation of 3-hydroxy-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxy-phenyl)-1,5-benzothiazepine-4(5H)-one | ORION CORPORATION FERMION (FI) | 1997-09-02 | — | — | US | claimed |
| EP-0702009-A1 | Method for the preparation of 3-hydroxy-5-(2-(dimethylamino)-ethy1)-2,3-dihydro-4-(methoxyphenyl)-1,5-benzothiazepin-4(5H)-one and use of the product for making pharmaceutically active compounds | Orion Corporation Fermion (FI) | 1996-03-20 | — | — | EP | claimed |
| EP-0488210-B1 | Process for preparing 1,5-benzothiazepine derivative | TANABE SEIYAKU CO (JP) | 1994-06-22 | — | — | EP | claimed |
| US-5169946-A | Reacting 3-hydroxy-2,3-dihydro-5- 2-dimethyl-amino)ethyl!-2-(p-methoxyphenyl)-1,5 -benzothiazepine-4(5H)-one with acetyl chloride in acetic acid; one step | TANABE SEIYAKU CO., LTD. (JP) | 1992-12-08 | — | — | US | claimed |
| EP-0488210-A1 | Process for preparing 1,5-benzothiazepine derivative | TANABE SEIYAKU CO., LTD. (JP) | 1992-06-03 | — | — | EP | claimed |
| EP-0154895-B1 | NEW SULFONIC RESINS HAVING A THERAPEUTICAL ACTIVITY, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ISTITUTO LUSO FARMACO D'ITALIA S.p.A. (IT) | 1992-05-06 | — | — | EP | claimed |
| EP-0433683-A2 | Use of benzothiazepines as potentiators of anti-cancer drugs | MARION MERRELL DOW INC. (US) | 1991-06-26 | — | — | EP | claimed |
| EP-0430036-A2 | Benzothiazepine metastasis treatment | MARION MERRELL DOW INC. (US) | 1991-06-05 | — | — | EP | claimed |
| US-4587242-A | TIME-RELEASE, SULFONATED STYRENE-DIVINYLBENZENE RESINS AND SALTS WITH THE DRUGS | INSTITUTO LUSOFARMACO D'ITALIA S.P.A. (IT) | 1986-05-06 | — | — | US | claimed |
| JP-5202013-A | — | — | None | — | — | JP | disclosed |
| JP-5043564-A | — | — | None | — | — | JP | disclosed |
| JP-56156218-A | — | — | None | — | — | JP | disclosed |
| JP-8269026-A | — | — | None | — | — | JP | disclosed |
| JP-8269026-A | — | — | None | — | — | JP | disclosed |
| US-4521430-A | VASODILATOR, ANTIISCHEMIC AGENT | TANABE SEIYAKU CO., LTD. (JP) | 1985-06-04 | — | — | US | disclosed |
| EP-0128462-A1 | Novel benzothiazepine derivatives, processes for preparing the same and pharmaceutical compositions | Tanabe Seiyaku Co., Ltd. (JP) | 1984-12-19 | — | — | EP | disclosed |
| EP-0107149-A1 | Novel naphthalene derivatives and method for preparation thereof | Tanabe Seiyaku Co., Ltd. (JP) | 1984-05-02 | — | — | EP | disclosed |
| US-4438035-A | Method of preparing benzothiazepine derivatives | TANABE SEIYAKU CO., LTD. (JP) | 1984-03-20 | — | — | US | disclosed |
| JP-S56156218-A | INHIBITOR AGAINST BLOOD PLATELET AGGLUTINATION | TANABE SEIYAKU CO LTD | 1981-12-02 | — | — | JP | disclosed |