Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 16/20 | 0.71 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL762103 | 0.85 | SYK (0.93) | SYKMAPK8MAPK9 | |
| SCHEMBL4419290 | 0.85 | SYK (0.84) | SYKMAPK8MAPK9 | |
| SCHEMBL4419303 | 0.85 | SYK (0.84) | SYKMAPK8MAPK9 | |
| SCHEMBL761163 | 0.84 | SYK (1.00) | SYKMAPK8 | |
| SCHEMBL735000 | 0.83 | SYK (0.73) | SYKMAPK8MAPK9 | |
| SCHEMBL734999 | 0.83 | SYK (0.73) | SYKMAPK8MAPK9 | |
| SCHEMBL29865420 | 0.82 | SYK (0.74) | SYKALDH1A1 | |
| SCHEMBL760627 | 0.82 | SYK (0.74) | SYKALDH1A1 | |
| SCHEMBL914462 | 0.78 | SYK (0.66) | SYK | |
| SCHEMBL20348692 | 0.78 | SYK (0.84) | SYKMAPK8MAPK9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138339-B2 | Inhibitors of protein kinases | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-03-20 | — | — | US | disclosed |