Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 4/20 | 0.68 |
| ▸ | AVPR2 | P30518 | 3/20 | 0.68 |
| ▸ | OXTR | P30559 | 2/20 | 0.68 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.68 |
| ▸ | HTR1A | P08908 | 1/20 | 0.68 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.68 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.68 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.68 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.68 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.68 |
| ▸ | QSOX1 | O00391 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7351658 | 0.88 | AVPR1A (0.79) | AVPR1AAVPR2OXTRABCB11HTR1A | |
| SCHEMBL7348059 | 0.88 | AVPR1A (0.70) | AVPR1AAVPR2OXTRABCB11HTR1A | |
| SCHEMBL4681873 | 0.88 | AVPR1A (0.70) | AVPR1AAVPR2OXTRABCB11HTR1A | |
| SCHEMBL7350027 | 0.87 | AVPR1A (0.69) | AVPR1AAVPR2OXTRABCB11HTR1A | |
| SCHEMBL7357937 | 0.84 | AVPR1A (0.66) | AVPR1AAVPR2OXTRABCB11HTR1A | |
| SCHEMBL7349407 | 0.84 | AVPR1A (0.72) | AVPR1AAVPR2OXTRABCB11HTR1A | |
| SCHEMBL4696573 | 0.83 | AVPR1A (0.75) | AVPR1AAVPR2OXTRABCB11HTR1A | |
| SCHEMBL7353560 | 0.82 | TSHR (0.72) | AVPR1AAVPR2OXTRALDH1A1LMNA | |
| Mozavaptan SCHEMBL1649322 | 0.81 | AVPR1A (1.00) | AVPR1AAVPR2OXTRABCB11HTR1A | |
| SCHEMBL7348562 | 0.81 | TSHR (0.70) | AVPR1AAVPR2OXTRALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5985869-A | USEFUL AS VASODILATORS, HYPOTENSIVE AGENTS, WATER DIURETICS, PLATELET AGGLUTINATION INHIBITORS | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1999-11-16 | — | — | US | disclosed |
| US-5753677-A | Benzoheterocyclic compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| US-5559230-A | VASOPRESSIN ANTAGONISTS, QUINOLINES, BENZAZEPINES, VASODILATION, HYPOTENSIVE AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-09-24 | — | — | US | disclosed |
| EP-0450097-B1 | BENZOHETEROCYCLIC COMPOUNDS | OTSUKA PHARMA CO LTD (JP) | 1996-04-24 | — | — | EP | disclosed |
| WO-1991005549-A1 | BENZOHETEROCYCLIC COMPOUNDS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-05-02 | — | — | WO | disclosed |