Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 7/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.37 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.36 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | HPD | P32754 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL734271 | 0.82 | PIK3CG (0.38) | PIK3CGPOLBRECQLPIK3CDPIK3C3 | |
| SCHEMBL734272 | 0.82 | PIK3CG (0.61) | PIK3CGPOLBRECQLPIK3CDPIK3CB | |
| SCHEMBL735173 | 0.80 | PIK3CG (0.51) | PIK3CGPOLBRECQLPIK3CDPIK3CB | |
| SCHEMBL1460987 | 0.77 | PIK3CG (0.54) | PIK3CGPOLBRECQLPIK3CDPIK3CB | |
| SCHEMBL16677424 | 0.74 | PIK3CD (0.62) | PIK3CGPIK3CDPIK3C3PIK3R1PIK3CA | |
| SCHEMBL16677626 | 0.74 | PIK3CD (0.62) | PIK3CGPIK3CDPIK3C3PIK3R1PIK3CA | |
| SCHEMBL16677702 | 0.74 | PIK3CD (0.62) | PIK3CGPIK3CDPIK3C3PIK3R1PIK3CA | |
| SCHEMBL734505 | 0.74 | PIK3CG (0.39) | PIK3CGPOLBRECQLPIK3CDPIK3C3 | |
| SCHEMBL734506 | 0.73 | PIK3CG (0.63) | PIK3CGPOLBRECQLPIK3CDPIK3CB | |
| SCHEMBL734435 | 0.73 | PIK3CG (0.39) | PIK3CGPOLBRECQLPIK3CDPIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138195-B2 | Inhibitors of human phosphatidylinositol 3-kinase delta | ICOS CORPORATION (US) | 2012-03-20 | — | — | US | disclosed |
| US-20050261317-A1 | Inhibitors of human phosphatidylinositol 3-kinase delta | ICOS CORPORATION (US) | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261317-A1 | Inhibitors of human phosphatidylinositol 3-kinase delta | PIK3CD, PIK3R5, PIK3CA | PIK3CG 4/4885POLB 933/4885RECQL 3005/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.