Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.75 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.75 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.75 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.75 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | AVPR2 | P30518 | 10/20 | 0.65 |
| ▸ | AVPR1A | P37288 | 9/20 | 0.65 |
| ▸ | TSHR | P16473 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | OXTR | P30559 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29941834 | 0.86 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7022992 | 0.86 | AVPR2 (0.61) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7018541 | 0.85 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7356848 | 0.85 | AVPR2 (0.69) | PDE4APDE4BPDE4CPDE4DAVPR2 | |
| SCHEMBL7024013 | 0.84 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL31058510 | 0.84 | PDE4A (0.75) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7352132 | 0.83 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7348149 | 0.83 | PDE4B (0.69) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL8562598 | 0.81 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7347092 | 0.79 | AVPR2 (1.00) | LMNAAVPR2AVPR1ATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5985869-A | USEFUL AS VASODILATORS, HYPOTENSIVE AGENTS, WATER DIURETICS, PLATELET AGGLUTINATION INHIBITORS | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1999-11-16 | — | — | US | disclosed |
| US-5753677-A | Benzoheterocyclic compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| US-5559230-A | VASOPRESSIN ANTAGONISTS, QUINOLINES, BENZAZEPINES, VASODILATION, HYPOTENSIVE AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-09-24 | — | — | US | disclosed |
| EP-0450097-B1 | BENZOHETEROCYCLIC COMPOUNDS | OTSUKA PHARMA CO LTD (JP) | 1996-04-24 | — | — | EP | disclosed |
| EP-0450097-A1 | BENZOHETEROCYCLIC COMPOUNDS. | OTSUKA PHARMA CO LTD (JP) | 1991-10-09 | — | — | EP | disclosed |
| WO-1991005549-A1 | BENZOHETEROCYCLIC COMPOUNDS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-05-02 | — | — | WO | disclosed |