Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.60 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | PPARD | Q03181 | 1/20 | 0.50 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.50 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 5/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27836648 | 1.00 | ZDHHC7 (0.60) | ZDHHC7LCKPPARDZDHHC20ZDHHC2 | |
| SCHEMBL729131 | 1.00 | ZDHHC7 (0.60) | ZDHHC7LCKPPARDZDHHC20ZDHHC2 | |
| SCHEMBL1566554 | 0.94 | ZDHHC7 (0.69) | ZDHHC7LCKPPARDZDHHC20ZDHHC2 | |
| SCHEMBL8321622 | 0.92 | ZDHHC7 (0.72) | ZDHHC7LCKPPARDZDHHC20ZDHHC2 | |
| SCHEMBL7789723 | 0.92 | ZDHHC7 (0.72) | ZDHHC7LCKPPARDZDHHC20ZDHHC2 | |
| SCHEMBL5708286 | 0.92 | ZDHHC7 (0.72) | ZDHHC7LCKPPARDZDHHC20ZDHHC2 | |
| SCHEMBL9548556 | 0.92 | ZDHHC7 (0.72) | ZDHHC7LCKPPARDZDHHC20ZDHHC2 | |
| SCHEMBL4704070 | 0.92 | ZDHHC7 (0.72) | ZDHHC7LCKPPARDZDHHC20ZDHHC2 | |
| SCHEMBL2721129 | 0.92 | ZDHHC7 (0.72) | ZDHHC7LCKPPARDZDHHC20ZDHHC2 | |
| SCHEMBL1007430 | 0.92 | ZDHHC7 (0.72) | ZDHHC7LCKPPARDZDHHC20ZDHHC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5389647-A | A prodrugs as hypotensive agents, treating congestive heart failure, urogenital disorders, vision defects | ABBOTT LABORATORIES (US) | 1995-02-14 | — | — | US | disclosed |
| US-5244910-A | Treating hypertension, congestive heart failure | ABBOTT LABORATORIES (US) | 1993-09-14 | — | — | US | disclosed |
| EP-0543936-A4 | RENIN INHIBITORS | — | 1993-06-30 | — | — | EP | disclosed |
| EP-0543936-A1 | RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1993-06-02 | — | — | EP | disclosed |
| WO-1992003429-A1 | RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1992-03-05 | — | — | WO | disclosed |