Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.81 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6369018 | 1.00 | TDP1 (0.81) | TDP1LMNASLC6A2SLC6A3KMT2A | |
| SCHEMBL7295230 | 1.00 | TDP1 (0.81) | TDP1LMNASLC6A2SLC6A3KMT2A | |
| SCHEMBL7296129 | 0.98 | TDP1 (0.85) | TDP1LMNASLC6A2SLC6A3KMT2A | |
| SCHEMBL7288016 | 0.92 | TDP1 (0.81) | TDP1LMNASLC6A2SLC6A3KMT2A | |
| SCHEMBL2069111 | 0.92 | TDP1 (0.96) | TDP1LMNASLC6A2SLC6A3KMT2A | |
| SCHEMBL17466182 | 0.92 | TDP1 (0.96) | TDP1LMNASLC6A2SLC6A3KMT2A | |
| SCHEMBL11896606 | 0.92 | TDP1 (0.96) | TDP1LMNASLC6A2SLC6A3KMT2A | |
| SCHEMBL223238 | 0.92 | TDP1 (0.96) | TDP1LMNASLC6A2SLC6A3KMT2A | |
| SCHEMBL225815 | 0.92 | TDP1 (0.96) | TDP1LMNASLC6A2SLC6A3KMT2A | |
| SCHEMBL11896235 | 0.92 | TDP1 (0.96) | TDP1LMNASLC6A2SLC6A3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100562511-C | 2-aryl-acetic acids, their derivative and contain their pharmaceutical composition | DOMPE SPA (IT) | 2009-11-25 | — | — | CN | claimed |
| US-5652247-A | VASOPRESSIN ANTAGONIST | OTSUKA PHARMACEUTICAL CO., LTD (JP) | 1997-07-29 | — | — | US | disclosed |
| US-5436254-A | Vaopressin antagonists | OTSUKA PHARMACEUTICAL COMPANY, LTD. (JP) | 1995-07-25 | — | — | US | disclosed |
| EP-0602209-A1 | OXYTOCIN ANTAGONIST | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-06-22 | — | — | EP | disclosed |
| EP-0382185-B1 | Carbostyril derivatives | OTSUKA PHARMA CO LTD (JP) | 1994-06-15 | — | — | EP | disclosed |
| WO-1994001113-A1 | OXYTOCIN ANTAGONIST | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1994-01-20 | — | — | WO | disclosed |
| US-5225402-A | Vasopressin antagonist, vasodilation, hypotensive, diuretics and anticoagulants | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-07-06 | — | — | US | disclosed |