SCHEMBL7353238

SCHEMBL7353238

ClC(Cl)OBOC(Cl)Cl

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7417410 0.67
SCHEMBL7357720 0.67
SCHEMBL11812657 0.53
SCHEMBL486684 0.53
SCHEMBL726519 0.50
SCHEMBL2032387 0.50
SCHEMBL28831336 0.50
SCHEMBL31400961 0.50
SCHEMBL292724 0.50
SCHEMBL62080 0.50

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1196436-A2 PEPTIDE BORONIC ACID INHIBITORS OF HEPATITIS C VIRUS PROTEASE Bristol-Myers Squibb Pharma Company (US) 2002-04-17 EP disclosed
WO-2001002424-A2 PEPTIDE BORONIC ACID INHIBITORS OF HEPATITIS C VIRUS PROTEASE DU PONT PHARMACEUTICALS COMPANY (US) 2001-01-11 WO disclosed
US-6060462-A Electrophilic peptide analogs as inhibitors of trypsin-like enzymes DUPONT PHARMACEUTICALS COMPANY (US) 2000-05-09 US disclosed
EP-0724446-A4 ELECTROPHILIC PEPTIDE ANALOGS AS INHIBITORS OF TRYPSIN-LIKE ENZYMES DU PONT MERCK PHARMA (US) 1998-01-07 EP disclosed
US-5658885-A OLIGOPEPTIDES; ANTICOAGULANTS; ENZYME INHIBITORS; THROMBIN THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) 1997-08-19 US disclosed
EP-0787010-A1 AMIDINO AND GUANIDINO SUBSTITUTED INHIBITORS OF TRYPSIN-LIKE ENZYMES THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1997-08-06 EP disclosed
EP-0696199-A4 AMIDINO AND GUANIDINO SUBSTITUTED BORONIC ACID INHIBITORS OF TRYPSIN-LIKE ENZYMES DU PONT MERCK PHARMA (US) 1997-06-25 EP disclosed
EP-0724446-A1 ELECTROPHILIC PEPTIDE ANALOGS AS INHIBITORS OF TRYPSIN-LIKE ENZYMES THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1996-08-07 EP disclosed
WO-1996012499-A1 AMIDINO AND GUANIDINO SUBSTITUTED INHIBITORS OF TRYPSIN-LIKE ENZYMES THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1996-05-02 WO disclosed
EP-0696199-A1 AMIDINO AND GUANIDINO SUBSTITUTED BORONIC ACID INHIBITORS OF TRYPSIN-LIKE ENZYMES THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1996-02-14 EP disclosed
WO-1995009634-A1 ELECTROPHILIC PEPTIDE ANALOGS AS INHIBITORS OF TRYPSIN-LIKE ENZYMES THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1995-04-13 WO disclosed
WO-1994025049-A1 AMIDINO AND GUANIDINO SUBSTITUTED BORONIC ACID INHIBITORS OF TRYPSIN-LIKE ENZYMES THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1994-11-10 WO disclosed
US-5169841-A Enzyme inhibitors, hypotensive agents, high enteral bioauailability HOECHST AKTIENGESELLSCHAFT (DE) 1992-12-08 US disclosed
US-4701545-A REACTING STERICALLY HINDERED BASE WITH MIXTURE OF DIHALOALKANE AND TRIALKYL BORATE WASHINGTON STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) 1987-10-20 US disclosed