Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CFD | P00746 | 2/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | F7 | P08709 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7353625 | 0.90 | PDE4A (0.50) | PDE4APDE4BNPC1RAB9AALDH1A1 | |
| SCHEMBL7933011 | 0.90 | PDE4B (0.67) | PDE4APDE4BNPC1RAB9AALDH1A1 | |
| Hydrochloric Acid SCHEMBL7346847 | 0.89 | PDE4B (0.66) | PDE4APDE4BNPC1RAB9AALDH1A1 | |
| SCHEMBL7355006 | 0.87 | PDE4A (0.50) | PDE4APDE4BNPC1RAB9AALDH1A1 | |
| SCHEMBL7352210 | 0.87 | PDE4A (0.55) | PDE4APDE4BNPC1RAB9AALDH1A1 | |
| SCHEMBL7355272 | 0.85 | PDE4A (0.51) | PDE4APDE4BNPC1RAB9AALDH1A1 | |
| SCHEMBL7361224 | 0.85 | PDE4A (0.53) | PDE4APDE4BNPC1RAB9AALDH1A1 | |
| SCHEMBL7352127 | 0.84 | PDE4A (0.47) | PDE4APDE4BNPC1RAB9AALDH1A1 | |
| SCHEMBL7359716 | 0.83 | PDE4B (0.46) | PDE4APDE4BNPC1RAB9AALDH1A1 | |
| SCHEMBL7353160 | 0.82 | PDE4A (0.44) | PDE4APDE4BNPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0834508-B1 | Substituted biphenyl or phenylpyridine derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2001-08-16 | — | — | EP | disclosed |
| US-5877190-A | PHOSPHODIESTERASE INHIBITOR | ADIR ET COMPAGNIE (FR) | 1999-03-02 | — | — | US | disclosed |
| EP-0834508-A1 | Substituted biphenyl or phenylpyridine derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1998-04-08 | — | — | EP | disclosed |