Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 1/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.38 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.38 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 5/20 | 0.33 |
| ▸ | HRH1 | P35367 | 3/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8117787 | 1.00 | GRIA1 (0.38) | GRIA1GRIA2GRIA3GRIA4KCNH2 | |
| SCHEMBL14287082 | 0.91 | HIF1A (0.33) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL14287109 | 0.89 | MAPK14 (0.38) | MAPK14SCN9A | |
| SCHEMBL4375379 | 0.89 | GRIA1 (0.38) | GRIA1GRIA2GRIA3GRIA4MCHR1 | |
| SCHEMBL4375384 | 0.89 | GRIA1 (0.38) | GRIA1GRIA2GRIA3GRIA4MCHR1 | |
| SCHEMBL8118359 | 0.88 | KCNH2 (0.37) | GRIA1GRIA2GRIA3GRIA4KCNH2 | |
| SCHEMBL14287114 | 0.87 | LRRK2 (0.37) | GRIA1GRIA2GRIA3GRIA4KCNH2 | |
| SCHEMBL7357256 | 0.87 | MEN1 (0.38) | GRIA1GRIA2GRIA3GRIA4MAPK14 | |
| SCHEMBL13592447 | 0.87 | GRIA1 (0.38) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL13592439 | 0.87 | GRIA1 (0.38) | GRIA1GRIA2GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0781284-B1 | INDOLE-2,3-DIONE-3-OXIME DERIVATIVES, THEIR PREPARATION AND USE | NEUROSEARCH AS (DK) | 2000-01-12 | — | — | EP | disclosed |
| US-5917053-A | INHIBITING GABA RELEASE FROM NEURONS | NEUROSEARCH A/S (DK) | 1999-06-29 | — | — | US | disclosed |
| US-5843945-A | AMPA antagonists and a method of treatment | NEUROSEARCH A/S (DK) | 1998-12-01 | — | — | US | disclosed |
| EP-0698025-B1 | AMPA ANTAGONISTS AND A METHOD OF TREATMENT THEREWITH | NEUROSEARCH AS (DK) | 1997-12-17 | — | — | EP | disclosed |
| EP-0781284-A1 | INDOLE-2,3-DIONE-3-OXIME DERIVATIVES, THEIR PREPARATION AND USE | NEUROSEARCH A/S (DK) | 1997-07-02 | — | — | EP | disclosed |
| WO-1996008494-A1 | INDOLE-2,3-DIONE-3-OXIME DERIVATIVES, THEIR PREPARATION AND USE | NEUROSEARCH A/S (DK) | 1996-03-21 | — | — | WO | disclosed |
| EP-0698025-A1 | AMPA ANTAGONISTS AND A METHOD OF TREATMENT THEREWITH | NEUROSEARCH A/S (DK) | 1996-02-28 | — | — | EP | disclosed |
| WO-1994026747-A1 | AMPA ANTAGONISTS AND A METHOD OF TREATMENT THEREWITH | NEUROSEARCH A/S (DK) | 1994-11-24 | — | — | WO | disclosed |