Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | ESRRG | P62508 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 6/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 4/20 | 0.38 |
| ▸ | PLG | P00747 | 3/20 | 0.38 |
| ▸ | PLAT | P00750 | 3/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.38 |
| ▸ | F2 | P00734 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27570130 | 0.82 | PLAU (0.56) | NPC1RAB9AESRRGNR1H4PLAU | |
| SCHEMBL7337293 | 0.81 | PLAU (0.60) | PLAUPLGPLATKLKB1PRSS1 | |
| Trifluoroacetic Acid SCHEMBL7334580 | 0.80 | ESRRG (0.43) | NPC1RAB9AESRRGPLAUPLG | |
| Trifluoroacetic Acid SCHEMBL7334595 | 0.80 | ESRRG (0.43) | NPC1RAB9AESRRGPLAUPLG | |
| Trifluoroacetic Acid SCHEMBL7335899 | 0.80 | PLAU (0.49) | NPC1RAB9AESRRGNR1H4PLAU | |
| SCHEMBL7337469 | 0.79 | PLAU (0.54) | NPC1RAB9APLAUPLGKLKB1 | |
| Trifluoroacetic Acid SCHEMBL7856169 | 0.77 | PLAU (0.54) | PLAUPLGPLATKLKB1PRSS1 | |
| SCHEMBL7345579 | 0.76 | PLAU (0.65) | NPC1RAB9ANR1H4PLAUPLG | |
| SCHEMBL17094907 | 0.76 | POLB (0.58) | NPC1RAB9AESRRGNR1H4EPHX2 | |
| SCHEMBL7343081 | 0.75 | PLAU (0.67) | NPC1RAB9ANR1H4PLAUPLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258822-B1 | ENZYME INHIBITORS OF NAPHTHALENE AMIDINE COMPOUNDS | ABBOTT LABORATORIES | 2001-07-10 | — | — | US | disclosed |