Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 6/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.64 |
| ▸ | PDE4A | P27815 | 2/20 | 0.64 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.64 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.55 |
| ▸ | SMPD1 | P17405 | 4/20 | 0.50 |
| ▸ | AHR | P35869 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7334347 | 0.89 | PDE4D (0.77) | PDE4BPDE4DPDE4APDE4CCYP2B6 | |
| SCHEMBL7362694 | 0.88 | PDE4B (0.82) | PDE4BPDE4DPDE4APDE4CCYP2B6 | |
| SCHEMBL7358420 | 0.81 | PDE4D (0.81) | PDE4BPDE4DPDE4APDE4CCYP2B6 | |
| SCHEMBL7357159 | 0.79 | PDE4B (0.92) | PDE4BPDE4DPDE4APDE4CCYP2B6 | |
| SCHEMBL7336155 | 0.78 | PDE4B (1.00) | PDE4BPDE4DPDE4APDE4CCYP2B6 | |
| SCHEMBL7361935 | 0.77 | PDE4B (0.94) | PDE4BPDE4DPDE4APDE4CCYP2B6 | |
| SCHEMBL985307 | 0.77 | PDE4B (0.82) | PDE4BPDE4DPDE4APDE4CCYP2B6 | |
| SCHEMBL6878175 | 0.77 | PDE4B (0.85) | PDE4BPDE4DPDE4APDE4CCYP2B6 | |
| SCHEMBL7334333 | 0.77 | PDE4B (0.92) | PDE4BPDE4DPDE4APDE4CCYP2B6 | |
| SCHEMBL7339491 | 0.77 | PDE4B (0.92) | PDE4BPDE4DPDE4APDE4CCYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | claimed |
| EP-0741707-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1996-11-13 | — | — | EP | claimed |
| WO-1995020578-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-08-03 | — | — | WO | claimed |
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | disclosed |
| EP-0741707-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995020578-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-08-03 | — | — | WO | disclosed |