Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7355122 | 1.00 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL5357871 | 0.91 | NPC1 (0.49) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL5357875 | 0.91 | NPC1 (0.49) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL14575533 | 0.91 | NPC1 (0.49) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL7380651 | 0.87 | PDE4B (0.66) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL7436899 | 0.86 | PDE4B (0.68) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5355688 | 0.83 | MAPK1 (0.47) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL5349673 | 0.83 | MAPK1 (0.47) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL5355685 | 0.83 | MAPK1 (0.47) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL5355537 | 0.83 | MAPK1 (0.47) | PDE4APDE4BPDE4CPDE4DNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458787-B1 | NOVEL PYRROLIDINE COMPOUNDS THAT ARE POTENT AND SELECTIVE INHIBITORS OF PDE4, AS WELL AS METHODS OF MAKING THE SAME, ARE DISCLOSED. USE OF THE COMPOUNDS IN THE TREATMENT OF INFLAMMATORY DISEASES AND OTHER DISEASES INVOLVING ELEVATED | ICOS CORPORATION | 2002-10-01 | — | — | US | disclosed |
| US-6258833-B1 | ENZYME INHIBITORS AND ANTIINFLAMMATORY AGENTS | ICOS CORPORATION | 2001-07-10 | — | — | US | disclosed |