Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 5/20 | 0.61 |
| ▸ | RARB | P10826 | 2/20 | 0.59 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | CA4 | P22748 | 1/20 | 0.58 |
| ▸ | CA6 | P23280 | 1/20 | 0.58 |
| ▸ | CA7 | P43166 | 1/20 | 0.58 |
| ▸ | TPMT | P51580 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.55 |
| ▸ | PDE4A | P27815 | 1/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3884522 | 0.93 | SMPD1 (0.68) | SMPD1PLA2G4BCA12CA1CA2 | |
| SCHEMBL4496535 | 0.90 | SMPD1 (0.72) | SMPD1PLA2G4BCA12CA1CA2 | |
| SCHEMBL28051119 | 0.89 | SMPD1 (0.75) | SMPD1PLA2G4BCA12CA1CA2 | |
| SCHEMBL9305512 | 0.89 | SMPD1 (0.75) | SMPD1PLA2G4BCA12CA1CA2 | |
| SCHEMBL28604170 | 0.89 | SMPD1 (0.75) | SMPD1PLA2G4BCA12CA1CA2 | |
| SCHEMBL7361115 | 0.88 | PDE4B (0.57) | SMPD1RARBPLA2G4BPDE4BPDE4A | |
| SCHEMBL3371069 | 0.87 | TSHR (0.66) | SMPD1PLA2G4BCA12CA1CA2 | |
| SCHEMBL1750327 | 0.87 | TSHR (0.74) | SMPD1PLA2G4BCA12CA1CA2 | |
| SCHEMBL7334285 | 0.86 | CA12 (0.69) | SMPD1CA12CA1CA2CA4 | |
| SCHEMBL8137461 | 0.86 | TSHR (0.71) | PLA2G4BCA12CA1CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | disclosed |
| EP-0741707-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995020578-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-08-03 | — | — | WO | disclosed |