Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 12/20 | 0.84 |
| ▸ | HTR1A | P08908 | 1/20 | 0.83 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.83 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.83 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.83 |
| ▸ | HRH2 | P25021 | 1/20 | 0.83 |
| ▸ | HTR2A | P28223 | 1/20 | 0.83 |
| ▸ | HTR2C | P28335 | 1/20 | 0.83 |
| ▸ | HRH1 | P35367 | 1/20 | 0.83 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.83 |
| ▸ | DRD3 | P35462 | 1/20 | 0.83 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.83 |
| ▸ | HTR2B | P41595 | 1/20 | 0.83 |
| ▸ | HTR5A | P47898 | 1/20 | 0.83 |
| ▸ | HTR6 | P50406 | 1/20 | 0.83 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.83 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.83 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.83 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tecalcet SCHEMBL31424074 | 0.92 | CASR (1.00) | CASRHTR1AADRA2BADRA2CSLC6A2 | |
| Tecalcet SCHEMBL896469 | 0.92 | CASR (1.00) | CASRHTR1AADRA2BADRA2CSLC6A2 | |
| Tecalcet SCHEMBL1275509 | 0.92 | CASR (1.00) | CASRHTR1AADRA2BADRA2CSLC6A2 | |
| Tecalcet SCHEMBL30092843 | 0.92 | CASR (1.00) | CASRHTR1AADRA2BADRA2CSLC6A2 | |
| Tecalcet SCHEMBL31424064 | 0.92 | CASR (1.00) | CASRHTR1AADRA2BADRA2CSLC6A2 | |
| Tecalcet SCHEMBL311950 | 0.92 | CASR (1.00) | CASRHTR1AADRA2BADRA2CSLC6A2 | |
| Tecalcet SCHEMBL1178449 | 0.91 | CASR (1.00) | CASRHTR1AADRA2BADRA2CSLC6A2 | |
| Tecalcet SCHEMBL1178446 | 0.91 | CASR (1.00) | CASRHTR1AADRA2BADRA2CSLC6A2 | |
| Tecalcet SCHEMBL29374613 | 0.91 | CASR (1.00) | CASRHTR1AADRA2BADRA2CSLC6A2 | |
| SCHEMBL6222202 | 0.88 | CASR (0.93) | CASRHTR1AADRA2BADRA2CSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211244-B1 | AROMATIC AMINES FOR COMPLEXING CALCIUM | NPS PHARMACEUTICALS, INC. | 2001-04-03 | — | — | US | disclosed |