Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 20/20 | 0.74 |
| ▸ | PDE4A | P27815 | 13/20 | 0.66 |
| ▸ | PDE4B | Q07343 | 13/20 | 0.66 |
| ▸ | PDE4C | Q08493 | 13/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7355847 | 0.87 | PDE4D (0.75) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7358250 | 0.86 | PDE4D (0.73) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL2587167 | 0.85 | PDE4D (0.71) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL2587166 | 0.85 | PDE4D (0.71) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7360312 | 0.84 | PDE4D (0.68) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL28333697 | 0.84 | PDE4D (0.68) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL27895441 | 0.83 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7362118 | 0.83 | PDE4D (0.55) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL20817352 | 0.82 | PDE4D (0.54) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL20817359 | 0.82 | PDE4D (0.54) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105085429-B | Aromatic heterocyclic derivative and application thereof in medicines | 广东东阳光药业有限公司 | 2019-12-10 | — | — | CN | disclosed |
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | disclosed |
| EP-0741707-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995020578-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-08-03 | — | — | WO | disclosed |