SCHEMBL7356608

SCHEMBL7356608

C=CCOc1ccccc1C(CC)c1c(O)c2ccccc2oc1=O

nearest known ligand 0.59

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 5/20 0.59
NQO1 P15559 2/20 0.54
ADORA3 P0DMS8 1/20 0.50
VKORC1 Q9BQB6 3/20 0.48
MEN1 O00255 2/20 0.48
KMT2A Q03164 2/20 0.48
CA12 O43570 1/20 0.48
CA1 P00915 1/20 0.48
CA9 Q16790 1/20 0.48
KDM4E B2RXH2 1/20 0.47
ALDH1A1 P00352 1/20 0.47
ALB P02768 1/20 0.47
PCSK7 Q16549 1/20 0.47
HSD17B10 Q99714 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9277714 0.85 CYP2C9 (0.68) CYP2C9NQO1ADORA3VKORC1MEN1
SCHEMBL7379474 0.85 CYP2C9 (0.68) CYP2C9NQO1ADORA3VKORC1MEN1
SCHEMBL7356919 0.83 CYP2C9 (0.65) CYP2C9NQO1ADORA3VKORC1MEN1
SCHEMBL9205338 0.83 CYP2C9 (0.65) CYP2C9NQO1ADORA3VKORC1MEN1
SCHEMBL9202623 0.81 CYP2C9 (0.65) CYP2C9NQO1VKORC1MEN1KMT2A
SCHEMBL7353313 0.81 CYP2C9 (0.65) CYP2C9NQO1VKORC1MEN1KMT2A
SCHEMBL8042698 0.79 CYP2C9 (0.86) CYP2C9NQO1ADORA3VKORC1MEN1
SCHEMBL7350378 0.77 CYP2C9 (0.70) CYP2C9NQO1ADORA3VKORC1MEN1
SCHEMBL2150156 0.76 HPGD (0.45) MEN1KMT2ACA12CA1CA9
SCHEMBL27418866 0.76 CYP2C9 (0.61) CYP2C9NQO1VKORC1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0682663-B1 4-HYDROXY-BENZOPYRAN-2-ONES AND 4-HYDROXY-CYCLOALKYL B]PYRAN-2-ONES USEFUL TO TREAT RETROVIRAL INFECTIONS UPJOHN CO (US) 2001-04-18 EP claimed
US-5686486-A 4-hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl b!pyran-2-ones useful to treat retroviral infections PHARMACIA & UPJOHN COMPANY (US) 1997-11-11 US claimed
EP-0682663-A1 4-HYDROXY-BENZOPYRAN-2-ONES AND 4-HYDROXY-CYCLOALKYL B]PYRAN-2-ONES USEFUL TO TREAT RETROVIRAL INFECTIONS PHARMACIA & UPJOHN COMPANY (US) 1995-11-22 EP claimed
WO-1994018188-A1 4-HYDROXY-BENZOPYRAN-2-ONES AND 4-HYDROXY-CYCLOALKYL[B]PYRAN-2-ONES USEFUL TO TREAT RETROVIRAL INFECTIONS THE UPJOHN COMPANY (US) 1994-08-18 WO claimed
EP-0682663-B1 4-HYDROXY-BENZOPYRAN-2-ONES AND 4-HYDROXY-CYCLOALKYL B]PYRAN-2-ONES USEFUL TO TREAT RETROVIRAL INFECTIONS UPJOHN CO (US) 2001-04-18 EP disclosed
US-5686486-A 4-hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl b!pyran-2-ones useful to treat retroviral infections PHARMACIA & UPJOHN COMPANY (US) 1997-11-11 US disclosed
EP-0682663-A1 4-HYDROXY-BENZOPYRAN-2-ONES AND 4-HYDROXY-CYCLOALKYL B]PYRAN-2-ONES USEFUL TO TREAT RETROVIRAL INFECTIONS PHARMACIA & UPJOHN COMPANY (US) 1995-11-22 EP disclosed
WO-1994018188-A1 4-HYDROXY-BENZOPYRAN-2-ONES AND 4-HYDROXY-CYCLOALKYL[B]PYRAN-2-ONES USEFUL TO TREAT RETROVIRAL INFECTIONS THE UPJOHN COMPANY (US) 1994-08-18 WO disclosed