Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 13/20 | 0.44 |
| ▸ | PDE4A | P27815 | 11/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7356763 | 1.00 | PDE4D (0.44) | PDE4DPDE4APDE4BPDE4CPDE3B | |
| SCHEMBL6858830 | 0.86 | PDE4A (0.43) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL6858833 | 0.86 | PDE4A (0.43) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7360858 | 0.85 | PDE4D (0.47) | PDE4DPDE4APDE4BPDE4CPDE3B | |
| SCHEMBL7360860 | 0.85 | PDE4D (0.47) | PDE4DPDE4APDE4BPDE4CPDE3B | |
| SCHEMBL7362314 | 0.75 | PDE4D (0.63) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL6865387 | 0.70 | PDE4A (0.54) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL6865130 | 0.70 | PDE4A (0.54) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL14402988 | 0.69 | PDE4D (0.42) | PDE4DPDE4APDE4BPDE4CERBB2 | |
| SCHEMBL7353099 | 0.69 | PDE4D (0.60) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | claimed |
| EP-0741707-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1996-11-13 | — | — | EP | claimed |
| WO-1995020578-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-08-03 | — | — | WO | claimed |
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | disclosed |
| EP-0741707-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995020578-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-08-03 | — | — | WO | disclosed |