Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.44 |
| ▸ | EGFR | P00533 | 3/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | BCR | P11274 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7830242 | 0.92 | MAPT (0.61) | MAPTNPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL6797321 | 0.90 | MAPT (0.55) | MAPTNPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL6798323 | 0.88 | MAPT (0.54) | MAPTNPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL6795443 | 0.87 | MAPT (0.53) | MAPTNPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL6796955 | 0.86 | ABCG2 (0.53) | MAPTNPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL6797852 | 0.84 | MAPT (0.50) | MAPTNPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL6798244 | 0.84 | MAPT (0.52) | MAPTNPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL6798198 | 0.83 | MAPT (0.49) | MAPTNPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL6792229 | 0.83 | MEN1 (0.59) | MAPTNPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL6798852 | 0.83 | MAPT (0.49) | MAPTNPC1RAB9AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874845-B1 | PYRIDO (2,3-B) PYRAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-03-06 | — | — | EP | disclosed |
| CN-1066732-C | Pyrido (2,3-b) pyrazine derivatives | FUJISAWA PHARMACEUTICAL CO (JP) | 2001-06-06 | — | — | CN | disclosed |
| US-6117875-A | Pyrido (2,3-B) pyrazine derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-09-12 | — | — | US | disclosed |
| CN-1205702-A | Pyrido (2,3-b) pyrazine derivatives | FUJISAWA PHARMACEUTICAL CO (JP) | 1999-01-20 | — | — | CN | disclosed |
| EP-0874845-A1 | PYRIDO (2,3-B) PYRAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997024355-A1 | PYRIDO (2,3-B) PYRAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-07-10 | — | — | WO | disclosed |