Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 3/20 | 0.57 |
| ▸ | PDE4A | P27815 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | F7 | P08709 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7352248 | 0.91 | PDE4A (0.44) | PDE4BPDE4AKMT2AMAPTALDH1A1 | |
| SCHEMBL7350348 | 0.85 | PDE4B (0.61) | PDE4BPDE4ALMNAKMT2AHPGD | |
| SCHEMBL7359007 | 0.85 | PDE4B (0.56) | PDE4BPDE4ALMNAKMT2AHPGD | |
| SCHEMBL7354545 | 0.82 | PDE4B (0.62) | PDE4BPDE4ALMNAKMT2AHPGD | |
| SCHEMBL7355534 | 0.81 | PDE4B (0.59) | PDE4BPDE4ALMNAKMT2AHPGD | |
| SCHEMBL7357303 | 0.80 | PDE4B (0.59) | PDE4BPDE4ALMNAKMT2AHPGD | |
| SCHEMBL7359063 | 0.80 | PDE4B (0.57) | PDE4BPDE4ALMNAKMT2AHPGD | |
| SCHEMBL7940588 | 0.80 | PDE4B (0.57) | PDE4BPDE4ALMNAKMT2AHPGD | |
| SCHEMBL7940610 | 0.79 | PDE4B (0.59) | PDE4BPDE4ALMNAKMT2AHPGD | |
| Hydrochloric Acid SCHEMBL7359055 | 0.79 | PDE4B (0.56) | PDE4BPDE4ALMNAKMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0834508-B1 | Substituted biphenyl or phenylpyridine derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2001-08-16 | — | — | EP | disclosed |
| US-5877190-A | PHOSPHODIESTERASE INHIBITOR | ADIR ET COMPAGNIE (FR) | 1999-03-02 | — | — | US | disclosed |
| EP-0834508-A1 | Substituted biphenyl or phenylpyridine derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1998-04-08 | — | — | EP | disclosed |