Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7327022 | 0.84 | KCNH2 (0.56) | KDM4EPOLBKCNH2GAAHTT | |
| SCHEMBL7333098 | 0.84 | KCNH2 (0.54) | KDM4EPOLBKCNH2GAAHTT | |
| SCHEMBL9112143 | 0.83 | HTT (0.48) | KDM4EPOLBKCNH2GAAHTT | |
| Hydrochloric Acid SCHEMBL9113993 | 0.83 | KCNH2 (0.55) | KDM4EPOLBKCNH2GAAHTT | |
| SCHEMBL7358086 | 0.82 | KCNH2 (0.67) | KDM4EKCNH2GAASMN1; SMN2KMT2A | |
| Hydrochloric Acid SCHEMBL7333194 | 0.80 | KCNH2 (0.74) | KCNH2SMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL8630987 | 0.80 | KCNH2 (0.54) | KDM4EPOLBKCNH2HTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9280379 | 0.80 | KCNH2 (0.51) | KCNH2GAAHTTCA1CA2 | |
| SCHEMBL6184511 | 0.79 | KMT2A (0.62) | HTTSMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL27432980 | 0.78 | KDM4E (0.66) | KDM4EPOLBSMN1; SMN2CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0852142-A1 | Diamines in the treatment of arrhythmia | SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) | 1998-07-08 | — | — | EP | disclosed |
| EP-0639973-A1 | DIAMINES IN THE TREATMENT OF ARRHYTHMIA | SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) | 1995-03-01 | — | — | EP | disclosed |
| WO-1993023024-A1 | DIAMINES IN THE TREATMENT OF ARRHYTHMIA | SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) | 1993-11-25 | — | — | WO | disclosed |