Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | CYP1A1 | P04798 | 8/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.49 |
| ▸ | CYP1B1 | Q16678 | 8/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.49 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.42 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7353076 | 0.81 | GAA (0.52) | KDM4EALDH1A1MAPTPKMKMT2A | |
| SCHEMBL7353069 | 0.81 | GAA (0.52) | KDM4EALDH1A1MAPTPKMKMT2A | |
| SCHEMBL30736440 | 0.76 | CYP1A1 (0.73) | CYP1A1CYP1A2CYP1B1CYP2D6CYP2C8 | |
| SCHEMBL31436391 | 0.76 | CYP1A1 (0.73) | CYP1A1CYP1A2CYP1B1CYP2D6CYP2C8 | |
| SCHEMBL7350267 | 0.75 | MAPT (0.50) | KDM4EALDH1A1MAPTPKMKMT2A | |
| SCHEMBL7354408 | 0.75 | MAPT (0.50) | KDM4EALDH1A1MAPTPKMKMT2A | |
| SCHEMBL11864000 | 0.71 | ABCG2 (0.81) | CYP1A1CYP1A2CYP1B1CYP2D6CYP2C8 | |
| SCHEMBL11864008 | 0.71 | ABCG2 (0.81) | CYP1A1CYP1A2CYP1B1CYP2D6CYP2C8 | |
| SCHEMBL7358999 | 0.71 | KDM4E (0.44) | KDM4EALDH1A1CYP3A4ACHE | |
| SCHEMBL6775493 | 0.71 | HSD17B10 (0.46) | KDM4EALDH1A1MAPTKMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0700383-B1 | NOVEL 1-PHENYLALKANONE 5-HT 4? RECEPTOR LIGANDS | SYNTEX INC (US) | 1998-09-23 | — | — | EP | disclosed |
| US-5763458-A | NERVOUS SYSTEM DISORDERS, ANXIETY, ANTIDEPRESSANTS AND COGNITION ACTIVATORS | SYNTEX (U.S.A.) INC. (US) | 1998-06-09 | — | — | US | disclosed |
| EP-0700383-A1 | NOVEL 1-PHENYLALKANONE 5-HT 4? RECEPTOR LIGANDS | SYNTEX (U.S.A.) INC. (US) | 1996-03-13 | — | — | EP | disclosed |
| WO-1994027965-A1 | NOVEL 1-PHENYLALKANONE 5-HT4 RECEPTOR LIGANDS | SYNTEX (U.S.A.) INC. (US) | 1994-12-08 | — | — | WO | disclosed |