Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7989912 | 0.99 | PDE4A (0.48) | PDE4APDE4DPDE4BPDE4CKDM4E | |
| SCHEMBL7388851 | 0.89 | PDE4A (0.47) | PDE4APDE4DPDE4BPDE4CKDM4E | |
| Hydrochloric Acid SCHEMBL7991157 | 0.81 | PDE4B (0.67) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7361347 | 0.74 | PDE4A (0.46) | PDE4APDE4DPDE4BPDE4CALDH1A1 | |
| Hydrochloric Acid SCHEMBL7989915 | 0.69 | PDE4A (0.47) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL18183564 | 0.68 | KDM4E (0.51) | KDM4EALDH1A1LMNA | |
| SCHEMBL4404454 | 0.67 | PDE4A (0.63) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL986245 | 0.66 | PDE4A (0.60) | PDE4APDE4DPDE4BPDE4CKDM4E | |
| SCHEMBL1157351 | 0.66 | PDE4A (0.58) | PDE4APDE4DPDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL8982808 | 0.66 | KDM4E (0.42) | KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1060173-A2 | BENZAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.p.A. (IT) | 2000-12-20 | — | — | EP | disclosed |
| WO-1999032449-A2 | BENZAZINE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.P.A. (IT) | 1999-07-01 | — | — | WO | disclosed |