Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.81 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.78 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.78 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7359401 | 1.00 | PDE4A (0.81) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7394569 | 0.93 | PDE4A (0.82) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6755269 | 0.92 | PDE4A (0.81) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL1387378 | 0.90 | PDE4A (1.00) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL1387472 | 0.90 | PDE4A (1.00) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL1387380 | 0.90 | PDE4A (1.00) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6755361 | 0.90 | PDE4A (0.95) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7361815 | 0.88 | PDE4A (0.81) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7364183 | 0.88 | PDE4A (0.77) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7364186 | 0.88 | PDE4A (0.77) | PDE4APDE4DPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0873310-A1 | DIPHENYL PYRIDYL ETHANE DERIVATIVES AS PDE IV INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1998-10-28 | — | — | EP | claimed |
| WO-1997022585-A1 | DIPHENYL PYRIDYL ETHANE DERIVATIVES AS PDE IV INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1997-06-26 | — | — | WO | claimed |