SCHEMBL7359506

SCHEMBL7359506

O=C(N[C@@H](Cc1nc2ccccc2s1)C(=O)O)OCc1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.58
L3MBTL1 Q9Y468 1/20 0.58
HDAC3 O15379 1/20 0.52
HDAC4 P56524 1/20 0.52
HDAC1 Q13547 1/20 0.52
HDAC7 Q8WUI4 1/20 0.52
HDAC2 Q92769 1/20 0.52
HDAC10 Q969S8 1/20 0.52
HDAC11 Q96DB2 1/20 0.52
HDAC8 Q9BY41 1/20 0.52
HDAC6 Q9UBN7 1/20 0.52
HDAC9 Q9UKV0 1/20 0.52
HDAC5 Q9UQL6 1/20 0.52
CYP3A4 P08684 3/20 0.49
TSHR P16473 1/20 0.49
HPGD P15428 1/20 0.49
CYP1A2 P05177 1/20 0.49
CYP2C19 P33261 1/20 0.49
MMP1 P03956 1/20 0.48
FCER2 P06734 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7359502 1.00 MAPK1 (0.58) MAPK1L3MBTL1HDAC3HDAC4HDAC1
Bromide SCHEMBL7418358 0.99 MAPK1 (0.57) MAPK1L3MBTL1HDAC3HDAC4HDAC1
Bromide SCHEMBL7418359 0.99 MAPK1 (0.57) MAPK1L3MBTL1HDAC3HDAC4HDAC1
SCHEMBL7419779 0.93 MAPK1 (0.58) MAPK1L3MBTL1HDAC3HDAC4HDAC1
SCHEMBL7419774 0.93 MAPK1 (0.58) MAPK1L3MBTL1HDAC3HDAC4HDAC1
SCHEMBL7418652 0.82 CYP3A4 (0.45) MAPK1L3MBTL1HDAC3HDAC4HDAC1
SCHEMBL7418647 0.82 CYP3A4 (0.45) MAPK1L3MBTL1HDAC3HDAC4HDAC1
SCHEMBL2804556 0.82 HDAC3 (0.52) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL26976628 0.81 MDM4 (0.54)
SCHEMBL26976589 0.81 MDM4 (0.54)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0815103-A1 TRYPSIN AND THROMBIN INHIBITORS Novartis AG (CH) 1998-01-07 EP disclosed
WO-1997046553-A1 THROMBIN INHIBITORS NOVARTIS AG (CH) 1997-12-11 WO disclosed
WO-1996029327-A1 TRYPSIN AND THROMBIN INHIBITORS NOVARTIS AG (CH) 1996-09-26 WO disclosed