Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 10/20 | 0.82 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MITF | O75030 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7359539 | 1.00 | SERPINE1 (0.82) | SERPINE1HRH3MAPTMAPK1PSEN1 | |
| SCHEMBL7358028 | 0.90 | SERPINE1 (1.00) | SERPINE1LMNAHPGDPIM1PIM2 | |
| SCHEMBL7358033 | 0.90 | SERPINE1 (1.00) | SERPINE1LMNAHPGDPIM1PIM2 | |
| SCHEMBL7353987 | 0.89 | SERPINE1 (1.00) | SERPINE1MAPTMEN1KMT2APIM1 | |
| SCHEMBL7363197 | 0.89 | SERPINE1 (0.82) | SERPINE1MAPTMEN1MITFALDH1A1 | |
| SCHEMBL7353995 | 0.89 | SERPINE1 (1.00) | SERPINE1MAPTMEN1KMT2APIM1 | |
| SCHEMBL7363192 | 0.89 | SERPINE1 (0.82) | SERPINE1MAPTMEN1MITFALDH1A1 | |
| SCHEMBL7359303 | 0.89 | SERPINE1 (1.00) | SERPINE1HRH3CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7359291 | 0.89 | SERPINE1 (1.00) | SERPINE1HRH3CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7357263 | 0.89 | SERPINE1 (0.79) | SERPINE1MAPTMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0760812-A1 | PHARMACEUTICAL DIKETOPIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1997-03-12 | — | — | EP | claimed |
| US-5750530-A | PLASMINOGEN ACTIVATOR INHIBITORS | XENOVA LIMITED (GB) | 1998-05-12 | — | — | US | disclosed |
| EP-0760812-A1 | PHARMACEUTICAL DIKETOPIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1997-03-12 | — | — | EP | disclosed |
| WO-1995032190-A2 | PHARMACEUTICAL DIKETOPIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1995-11-30 | — | — | WO | disclosed |