Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.68 |
| ▸ | ATM | Q13315 | 1/20 | 0.68 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 7/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13317191 | 0.86 | RECQL (0.61) | POLBRECQLPDE4BMEN1KMT2A | |
| SCHEMBL8570021 | 0.83 | MEN1 (0.61) | RECQLPDE4BMEN1KMT2AEPHX1 | |
| SCHEMBL8567718 | 0.83 | SMN1; SMN2 (0.55) | RECQLPDE4BMEN1KMT2AEPHX1 | |
| SCHEMBL8571660 | 0.83 | KMT2A (0.61) | RECQLPDE4BMEN1KMT2AEPHX1 | |
| SCHEMBL7353001 | 0.83 | KDM4E (0.66) | ATMRECQLPDE4BMEN1KMT2A | |
| SCHEMBL5610571 | 0.83 | RECQL (0.61) | POLBRECQLPDE4BPDE4APDE4C | |
| SCHEMBL557799 | 0.82 | ATM (1.00) | POLBATMKMT2AMAPTLMNA | |
| SCHEMBL30230461 | 0.82 | ATM (1.00) | POLBATMKMT2AMAPTLMNA | |
| SCHEMBL8635081 | 0.82 | ATM (1.00) | POLBATMKMT2AMAPTLMNA | |
| SCHEMBL7333965 | 0.82 | PDE4B (0.56) | RECQLPDE4BMEN1KMT2APDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710180-A | TREATING ALLERGIC AND INFLAMMATORY DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1998-01-20 | — | — | US | disclosed |
| EP-0714397-A4 | — | — | 1996-06-26 | — | — | EP | disclosed |
| EP-0714397-A1 | PHENETHYLAMINE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-06-05 | — | — | EP | disclosed |
| EP-0538384-A4 | OXAMIDES | SMITHKLINE BEECHAM CORP (US) | 1995-04-12 | — | — | EP | disclosed |
| US-5393788-A | Phenylalkyl oxamides | SMITHKLINE BEECHAM CORPORATION (US) | 1995-02-28 | — | — | US | disclosed |
| WO-1995005386-A1 | PHENETHYLAMINE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-02-23 | — | — | WO | disclosed |
| EP-0538384-A1 | OXAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-04-28 | — | — | EP | disclosed |
| WO-1992000968-A1 | OXAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 1992-01-23 | — | — | WO | disclosed |