Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.47 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.44 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.44 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 8/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10938346 | 0.91 | KDM4E (0.54) | TLR8KDM4EGABRA1GABRG2GABRB3 | |
| SCHEMBL7398126 | 0.91 | TLR8 (0.49) | TLR8KDM4EGABRA1GABRG2GABRB3 | |
| SCHEMBL10730802 | 0.91 | TLR8 (0.49) | TLR8KDM4EGABRA1GABRG2GABRB3 | |
| SCHEMBL10734105 | 0.89 | CDKN1A (0.49) | TLR8KDM4EGABRA1GABRG2GABRB3 | |
| SCHEMBL10735393 | 0.87 | KDM4E (0.56) | TLR8KDM4EGABRA1GABRG2GABRB3 | |
| SCHEMBL7364783 | 0.86 | TLR8 (0.50) | TLR8KDM4EGABRA1GABRG2GABRB3 | |
| SCHEMBL5821489 | 0.85 | CDKN1A (0.46) | TLR8KDM4EGABRA1GABRG2GABRB3 | |
| SCHEMBL5819907 | 0.85 | CDKN1A (0.61) | TLR8KDM4EGABRA1GABRG2GABRB3 | |
| SCHEMBL5823630 | 0.85 | KDM4E (0.53) | TLR8KDM4EGABRA1GABRG2GABRB3 | |
| SCHEMBL7398130 | 0.82 | CDKN1A (0.56) | TLR8MAPK13MARK2LIMK1CDKN1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4521422-A | ANTICONVULSANT, ANTIEPILEPTIC AGENTS, SEDATIVES, MUSCLE RELAXANTS | AMERICAN CYANAMID COMPANY (US) | 1985-06-04 | — | — | US | disclosed |
| EP-0129847-A2 | Aryl and heteroaryl[7-(aryl and heteroaryl)-pyrazolo-[1,5-a]-pyrimidin-3-yl]methanones | AMERICAN CYANAMID COMPANY (US) | 1985-01-02 | — | — | EP | disclosed |