Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 5/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.51 |
| ▸ | MAPK6 | Q16659 | 3/20 | 0.51 |
| ▸ | MAPKAPK3 | Q16644 | 2/20 | 0.51 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.50 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.48 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7362195 | 0.90 | MAP2K4 (0.57) | MAP2K4MAPK1MAPK6MAPKAPK3NCOA1 | |
| SCHEMBL7367837 | 0.88 | MAP2K4 (0.52) | MAP2K4MAPK1MAPK6MAPKAPK3NCOA1 | |
| SCHEMBL1251253 | 0.86 | NPSR1 (0.67) | ATMNPSR1ROCK2ROCK1KDM4E | |
| SCHEMBL7364011 | 0.85 | MAPK1 (0.73) | MAP2K4MAPK1NCOA1NCOA3ROCK2 | |
| SCHEMBL12326463 | 0.83 | ATM (0.72) | MAP2K4MAPK1NCOA1NCOA3ATM | |
| SCHEMBL7369415 | 0.82 | ATM (0.49) | MAP2K4MAPK1MAPK6MAPKAPK3NCOA1 | |
| SCHEMBL1251585 | 0.81 | NPSR1 (0.51) | MAPK1NCOA1NCOA3ATMNPSR1 | |
| SCHEMBL2887372 | 0.78 | KDM4E (0.54) | MAPK1ATMNPSR1ROCK2ROCK1 | |
| SCHEMBL7362532 | 0.78 | MAP2K4 (0.53) | MAP2K4MAPK1MAPK6MAPKAPK3NCOA1 | |
| SCHEMBL1252788 | 0.76 | IDO1 (0.55) | MAP2K4ATMNPSR1ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |