SCHEMBL7360935

SCHEMBL7360935

O=C(Nc1ccccc1)Oc1cccc2cccnc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 1.00
L3MBTL1 Q9Y468 4/20 0.67
SMN1; SMN2 Q16637 3/20 0.67
NPC1 O15118 1/20 0.67
RAB9A P51151 1/20 0.67
LMNA P02545 4/20 0.63
HDAC6 Q9UBN7 2/20 0.63
METAP2 P50579 2/20 0.63
METAP1 P53582 2/20 0.63
MAPT P10636 3/20 0.59
ALDH1A1 P00352 2/20 0.59
RXFP1 Q9HBX9 1/20 0.59
KMT2A Q03164 4/20 0.58
MEN1 O00255 3/20 0.58
NPSR1 Q6W5P4 2/20 0.56
HTT P42858 1/20 0.56
KDM4E B2RXH2 3/20 0.53
POLB P06746 1/20 0.53
EGLN1 Q9GZT9 1/20 0.52
USP2 O75604 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5245061 0.92 HSP90AA1 (0.85) HSP90AA1L3MBTL1SMN1; SMN2NPC1RAB9A
SCHEMBL4412821 0.90 HSP90AA1 (0.81) HSP90AA1L3MBTL1SMN1; SMN2NPC1RAB9A
SCHEMBL4409556 0.89 HSP90AA1 (0.79) HSP90AA1L3MBTL1SMN1; SMN2NPC1RAB9A
SCHEMBL4413967 0.86 HSP90AA1 (0.74) HSP90AA1L3MBTL1SMN1; SMN2NPC1RAB9A
SCHEMBL5254903 0.84 HSP90AA1 (0.72) HSP90AA1L3MBTL1SMN1; SMN2NPC1RAB9A
SCHEMBL4412612 0.84 HSP90AA1 (0.71) HSP90AA1L3MBTL1SMN1; SMN2NPC1RAB9A
SCHEMBL5252574 0.83 HSP90AA1 (0.71) HSP90AA1L3MBTL1SMN1; SMN2NPC1RAB9A
SCHEMBL6401291 0.83 HSP90AA1 (0.71) HSP90AA1L3MBTL1SMN1; SMN2NPC1RAB9A
SCHEMBL4411491 0.83 HSP90AA1 (0.69) HSP90AA1L3MBTL1SMN1; SMN2NPC1RAB9A
SCHEMBL5251620 0.82 HSP90AA1 (0.69) HSP90AA1L3MBTL1SMN1; SMN2NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5124455-A Enzyme inhibitors AMERICAN HOME PRODUCTS CORPORATION (US) 1992-06-23 US claimed
US-4710508-A ANALGESICS WARNER-LAMBERT COMPANY (US) 1987-12-01 US claimed
CN-113582889-A Sulfonylureas and related compounds and uses thereof 昆士兰大学 2021-11-02 CN disclosed
CN-113563264-A Sulfonylureas and related compounds and uses thereof 昆士兰大学 2021-10-29 CN disclosed
CN-107428696-B Sulfonylureas and related compounds and uses thereof 昆士兰大学 2021-08-20 CN disclosed
CN-107428696-A Sulfonylureas and related compounds and uses thereof 昆士兰大学 2017-12-01 CN disclosed
EP-0470805-B1 Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents AMERICAN HOME PROD (US) 1994-09-07 EP disclosed
US-5124455-A Enzyme inhibitors AMERICAN HOME PRODUCTS CORPORATION (US) 1992-06-23 US disclosed
EP-0470805-A1 Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents AMERICAN HOME PRODUCTS CORPORATION (US) 1992-02-12 EP disclosed
US-4710508-A ANALGESICS WARNER-LAMBERT COMPANY (US) 1987-12-01 US disclosed
US-4381935-A POSTEMERGENCE HERBICIDE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1983-05-03 US disclosed
US-3946016-A BACTERICIDES, FUNGICIDES R. T. VANDERBILT COMPANY, INC. (US) 1976-03-23 US disclosed