Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.44 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30562192 | 0.88 | HPGD (0.61) | HPGDTSHRSMN1; SMN2HTTL3MBTL1 | |
| SCHEMBL13003328 | 0.85 | TSHR (0.40) | HPGDTSHRSMN1; SMN2HTTL3MBTL1 | |
| SCHEMBL13060395 | 0.84 | HPGD (0.66) | HPGDHTTL3MBTL1MAPTRECQL | |
| SCHEMBL22518619 | 0.83 | SMN1; SMN2 (0.46) | TSHRSMN1; SMN2CHRNB2CHRNA3CHRNA4 | |
| SCHEMBL22518582 | 0.83 | SMN1; SMN2 (0.46) | TSHRSMN1; SMN2CHRNB2CHRNA3CHRNA4 | |
| SCHEMBL22518621 | 0.83 | SMN1; SMN2 (0.46) | TSHRSMN1; SMN2CHRNB2CHRNA3CHRNA4 | |
| SCHEMBL27039738 | 0.83 | HPGD (0.50) | HPGDTSHRSMN1; SMN2HTTL3MBTL1 | |
| SCHEMBL1457027 | 0.81 | EPHX2 (0.40) | SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL559976 | 0.81 | HRH3 (0.34) | TSHRSMN1; SMN2HTTL3MBTL1ALDH1A1 | |
| SCHEMBL15053338 | 0.80 | TSHR (0.48) | TSHRSMN1; SMN2ALDH1A1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5296479-A | Treating physiological or drug-induced psychosis or dyskinesia | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-03-22 | — | — | US | disclosed |
| US-5266572-A | Antipsychotic 1-cycloalkylpiperidines | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-11-30 | — | — | US | disclosed |
| US-5243048-A | Treatment of drug-induced or physiological psychosis or dyskinesia; side effect reduction | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-09-07 | — | — | US | disclosed |
| EP-0490962-A4 | ANTIPSYCHOTIC 1-CYCLOALKYLPIPERIDINES | — | 1993-03-03 | — | — | EP | disclosed |
| EP-0490962-A1 | ANTIPSYCHOTIC 1-CYCLOALKYLPIPERIDINES | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-06-24 | — | — | EP | disclosed |
| US-5109002-A | ANTIPSYCHOTIC 1-CYCLOALKYLPIPERIDINES | DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-04-28 | — | — | US | disclosed |
| WO-1991003243-A1 | ANTIPSYCHOTIC 1-CYCLOALKYLPIPERIDINES | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1991-03-21 | — | — | WO | disclosed |