Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 11/20 | 0.50 |
| ▸ | PREP | P48147 | 3/20 | 0.48 |
| ▸ | FAP | Q12884 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.46 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.44 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7365866 | 0.89 | ACE (0.48) | ACEPREPFAPLMNAACE2 | |
| SCHEMBL22811043 | 0.84 | ACE (0.50) | ACEPREPFAPLMNAACE2 | |
| SCHEMBL20355907 | 0.81 | PREP (0.48) | ACEPREPFAPLMNAACE2 | |
| SCHEMBL11435575 | 0.81 | ACE (0.71) | ACEPREPFAPACE2 | |
| SCHEMBL29749309 | 0.81 | ACE (0.71) | ACEPREPFAPACE2 | |
| SCHEMBL3472327 | 0.81 | ACE (0.71) | ACEPREPFAPACE2 | |
| SCHEMBL10654820 | 0.81 | ACE (0.49) | ACEPREPFAPLMNAACE2 | |
| SCHEMBL11104635 | 0.81 | ACE (0.55) | ACEPREPFAPLMNAACE2 | |
| SCHEMBL7363545 | 0.81 | ACE (0.51) | ACEPREPFAPACE2DPP8 | |
| SCHEMBL22209483 | 0.79 | PREP (0.52) | ACEPREPFAPLMNAACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5432159-A | N-(α-substituted-pyridinyl)carbonyl dipeptide antihypertensive agents | LACER S.A. (ES) | 1995-07-11 | — | — | US | disclosed |
| WO-1992015608-A1 | N-(α-SUBSTITUTED-PYRIDINYL)CARBONYL DIPEPTIDE ANTIHYPERTENSIVE AGENTS | LACER S.A. (ES) | 1992-09-17 | — | — | WO | disclosed |
| EP-0500989-A1 | N-(alpha-substituted-pyridinyl) carbonyl dipeptide antihypertensive agents | LACER, S.A. (ES) | 1992-09-02 | — | — | EP | disclosed |