Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.64 |
| ▸ | MEN1 | O00255 | 5/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | MGLL | Q99685 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5967465 | 0.84 | MEN1 (0.68) | KMT2AMEN1KDM4EGAAALDH1A1 | |
| SCHEMBL28520136 | 0.83 | MEN1 (0.65) | KMT2AMEN1KDM4EGAAALDH1A1 | |
| SCHEMBL18361680 | 0.77 | MEN1 (0.70) | KMT2AMEN1KDM4EGAAALDH1A1 | |
| SCHEMBL13103793 | 0.77 | KMT2A (0.66) | KMT2AMEN1KDM4EGAAALDH1A1 | |
| SCHEMBL9013562 | 0.76 | EPHX1 (0.71) | KMT2AMEN1GAAALDH1A1CYP2C9 | |
| SCHEMBL400282 | 0.76 | MEN1 (0.61) | KMT2AMEN1KDM4EGAAALDH1A1 | |
| SCHEMBL18361742 | 0.75 | MEN1 (0.67) | KMT2AMEN1ALDH1A1MAPTMAPK1 | |
| SCHEMBL22114353 | 0.74 | EPHX1 (0.64) | KMT2AMEN1KDM4EGAAALDH1A1 | |
| SCHEMBL3760386 | 0.74 | EPHX1 (0.68) | KMT2AMEN1GAAALDH1A1CYP2C9 | |
| SCHEMBL13102340 | 0.73 | KMT2A (0.61) | KMT2AMEN1KDM4EGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6037367-A | Substituted-pent-4-ynoic acids | SMITHKLINE BEECHAM CORPORATION (US) | 2000-03-14 | — | — | US | disclosed |
| EP-0827495-A4 | SUBSTITUTED-PENT-4-YNOIC ACIDS | SMITHKLINE BEECHAM CORP (US) | 1998-11-04 | — | — | EP | disclosed |
| EP-0827495-A1 | SUBSTITUTED-PENT-4-YNOIC ACIDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-03-11 | — | — | EP | disclosed |
| WO-1997003945-A1 | SUBSTITUTED-PENT-4-YNOIC ACIDS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-02-06 | — | — | WO | disclosed |