Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A1 | P04798 | 2/20 | 0.47 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 14/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.47 |
| ▸ | PDE4A | P27815 | 9/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7361766 | 1.00 | CYP1A1 (0.47) | CYP1A1CYP1B1CYP1A2PDE4DPDE4B | |
| SCHEMBL7354706 | 0.87 | CYP1A1 (0.47) | CYP1A1CYP1B1CYP1A2PDE4DPDE4B | |
| SCHEMBL7354702 | 0.87 | CYP1A1 (0.47) | CYP1A1CYP1B1CYP1A2PDE4DPDE4B | |
| SCHEMBL70934 | 0.85 | PDE4B (0.54) | CYP1A1CYP1B1CYP1A2PDE4DPDE4B | |
| SCHEMBL70933 | 0.85 | PDE4B (0.54) | CYP1A1CYP1B1CYP1A2PDE4DPDE4B | |
| SCHEMBL497696 | 0.78 | PDE4D (0.57) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL497697 | 0.78 | PDE4D (0.57) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL498305 | 0.78 | PDE4D (0.57) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL28372613 | 0.77 | KDM4E (0.61) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7353005 | 0.75 | PDE4D (0.48) | PDE4DPDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | claimed |
| EP-0741707-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1996-11-13 | — | — | EP | claimed |
| WO-1995020578-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-08-03 | — | — | WO | claimed |
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | disclosed |
| EP-0741707-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995020578-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-08-03 | — | — | WO | disclosed |