Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 20/20 | 0.77 |
| ▸ | PDE4A | P27815 | 19/20 | 0.77 |
| ▸ | PDE4B | Q07343 | 19/20 | 0.77 |
| ▸ | PDE4C | Q08493 | 19/20 | 0.77 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1554378 | 0.95 | PDE4D (0.86) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL1553933 | 0.90 | PDE4D (0.86) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL7359321 | 0.89 | PDE4D (0.67) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL7359327 | 0.89 | PDE4D (0.64) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL1552779 | 0.85 | PDE4D (0.68) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL1552882 | 0.84 | PDE4D (0.85) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL1553224 | 0.84 | PDE4D (0.70) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL1553036 | 0.84 | PDE4D (0.69) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL1553303 | 0.83 | PDE4D (0.64) | PDE4DPDE4APDE4BPDE4CPDE11A | |
| SCHEMBL1553096 | 0.83 | PDE4D (0.64) | PDE4DPDE4APDE4BPDE4CPDE11A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934307-A1 | SUBSTITUTED AZABICYLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF THE PRODUCTION OF TNF AND CYCLIC AMP PHOSPHODIESTERASE | RHONE-POULENC RORER LIMITED (GB) | 1999-08-11 | — | — | EP | claimed |
| WO-1997048697-A1 | SUBSTITUTED AZABICYLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF THE PRODUCTION OF TNF AND CYCLIC AMP PHOSPHODIESTERASE | RHONE-POULENC RORER LIMITED (GB) | 1997-12-24 | — | — | WO | claimed |