Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 18/20 | 0.48 |
| ▸ | PDE4A | P27815 | 9/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL70397 | 0.83 | KDM4E (0.53) | PDE4DPDE4APDE4BPDE4CKDM4E | |
| SCHEMBL7361121 | 0.80 | PDE4D (0.52) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL2905403 | 0.79 | PDE4D (0.44) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL2903176 | 0.79 | PDE4D (0.44) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7357361 | 0.76 | PDE4D (0.52) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7234015 | 0.74 | KDM4E (0.68) | KDM4EL3MBTL1 | |
| SCHEMBL17908087 | 0.74 | PDE4D (0.72) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7359837 | 0.74 | PDE4D (0.72) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL2586121 | 0.74 | PDE4D (0.72) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7360996 | 0.74 | PDE4D (0.72) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | disclosed |
| EP-0741707-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995020578-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-08-03 | — | — | WO | disclosed |