Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 3/20 | 0.40 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | PLAT | P00750 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6434174 | 0.90 | PLAU (0.50) | PLAUPLGPLATTHRBSCN9A | |
| Hydrochloric Acid SCHEMBL7372713 | 0.90 | PLAU (0.41) | PLAUPLGPLATTHRBSCN9A | |
| Hydrochloric Acid SCHEMBL6437764 | 0.89 | PLAU (0.49) | PLAUPLGPLATTHRBSCN9A | |
| SCHEMBL6437440 | 0.82 | PLAU (0.40) | PLAUPLGPLATSCN9A | |
| SCHEMBL6965041 | 0.80 | F2 (0.35) | PLAUPLGPLATSCN9A | |
| SCHEMBL7373625 | 0.80 | MEN1 (0.31) | PLAU | |
| SCHEMBL6434837 | 0.80 | PLAU (0.37) | PLAUPLGPLATSCN9A | |
| Hydrochloric Acid SCHEMBL6432755 | 0.80 | F2 (0.35) | PLAUPLGPLATSCN9A | |
| Hydrochloric Acid SCHEMBL6439059 | 0.79 | PLAU (0.40) | PLAUPLGPLATTHRB | |
| Hydrochloric Acid SCHEMBL6433670 | 0.79 | PLAU (0.51) | PLAUPLGPLATSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242120-A2 | COMBINATIONS OF GROWTH FACTORS AND I:UPA OR I:MMP FOR THE TREATMENT OF DAMAGED TISSUE | Pfizer Limited (GB) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001049309-A2 | COMBINATIONS OF GROWTH FACTORS AND I: UPA OR I: MMP FOR THE TREATMENT OF DAMAGED TISSUE | PFIZER LIMITED (GB) | 2001-07-12 | — | — | WO | disclosed |
| EP-1077945-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-2000005214-A2 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2000-02-03 | — | — | WO | disclosed |